Canada in Science - November 2023

Immune-privileged tissues formed from immunologically cloaked mouse embryonic stem cells survive long term in allogeneic hosts

Journal Issue: Nat Biomed Eng. 2023 Nov 23. doi: 10.1038/s41551-023-01133-y.

Authors: Harding J, Vintersten-Nagy K, Yang H, Tang JK, Shutova M, Jong ED, Lee JH, Massumi M, Oussenko T, Izadifar Z, Zhang P, Rogers IM, Wheeler MB, Lye SJ, Sung HK, Li C, Izadifar M, Nagy A.

PubMed ID: 37996616

Andras Nagy Lab

The tumor-derived cytokine Chi3l1 induces neutrophil extracellular traps that promote T cell exclusion in triple-negative breast cancer

Journal Issue: Immunity. 2023 Nov 18:S1074-7613(23)00483-1.

Authors: Taifour T, Attalla SS, Zuo D, Gu Y, Sanguin-Gendreau V, Proud H, Solymoss E, Bui T, Kuasne H, Papavasiliou V, Lee CG, Kamle S, Siegel PM, Elias JA, Park M, Muller WJ.

PubMed ID: 38039967

William Muller Lab

A longitudinal single-cell atlas of treatment response in pediatric AML

Journal Issue: Cancer Cell. 2023 Nov 8:S1535-6108(23)00364-1.

Authors: Lambo S, Trinh DL, Ries RE, Jin D, Setiadi A, Ng M, Leblanc VG, Loken MR, Brodersen LE, Dai F, Pardo LM, Ma X, Vercauteren SM, Meshinchi S, Marra MA.

PubMed ID: 37977148

Marco Marra Lab

Reactive Oxygen Species Modulator 1 (ROMO1) Plays an Obligate Role in Cardiomyocyte Hypertrophy

Journal Issue: Circ Res. 2023 Nov 29. doi: 10.1161/CIRCRESAHA.123.323456.

Authors: Martens MD, Holody CD, Wells L, Silver HL, Morales-Llamas DY, Du WW, Reeks C, Khairy M, Chen H, Ferdaoussi M, Bourque SL, Yang BB, Ussher JR, Lemieux H, Oudit GY, Screaton RA, Dyck JRB.

PubMed ID: 37977148

Jason Dyck Lab

The extrafollicular B cell response is a hallmark of childhood idiopathic nephrotic syndrome

Journal Issue: Nat Commun. 2023 Nov 24;14(1):7682.

Authors: Al-Aubodah TA, Aoudjit L, Pascale G, Perinpanayagam MA, Langlais D, Bitzan M, Samuel SM, Piccirillo CA, Takano T.

PubMed ID: 37996443

Tomoko Takano Lab