October 7, 2021

Canada in Science - October 7, 2021

Proc Natl Acad Sci USA. 2021 Sep 21;118(38):e2101592118.

Therapeutic inhibition of USP9x-mediated Notch signaling in triple-negative breast cancer


Nat Commun. 2021 Sep 9;12(1):5354.

ORP1L mediated PI(4)P signaling at ER-lysosome-mitochondrion three-way contact contributes to mitochondrial division/


Nat Commun. 2021 Sep 29;12(1):5711.

Unraveling the functional role of DNA demethylation at specific promoters by targeted steric blockage of DNA methyltransferase with CRISPR/dCas9


Nat Commun. 2021 Sep 13;12(1):5404.

SMARCA4/2 loss inhibits chemotherapy-induced apoptosis by restricting IP3R3-mediated Ca 2+ flux to mitochondria


Mol Cell. 2021 Sep 16;81(18):3848-3865.e19.

A hydride transfer complex reprograms NAD metabolism and bypasses senescence