September 10, 2021

Canada in Science - September 10, 2021

Nat Med. 2021 Jul;27(7):1272-1279. doi: 10.1038/s41591-021-01399-2.

Fecal microbial transplantation and fiber supplementation in patients with severe obesity and metabolic syndrome: a randomized double-blind, placebo-controlled Phase 2 trial

Nature. 2021 Jul 7. doi: 10.1038/s41586-021-03744-4.

Antibody epitopes in vaccine-induced immune thrombotic thrombocytopaenia

Nature. 2021 Jul;595(7865):120-124. doi: 10.1038/s41586-021-03592-2.

A proximity-dependent biotinylation map of a human cell

Science. 2021 Jul 9;373(6551):eabf6202. doi: 10.1126/science.abf6202.

Mapping the cellular origin and early evolution of leukemia in Down syndrome

Nature. 2021 Jul;595(7868):585-590. doi: 10.1038/s41586-021-03648-3.

Computational modeling of ovarian cancer dynamics suggests optimal strategies for therapy and screening

Nature. 2021 Aug;596(7871):257-261. doi: 10.1038/s41586-021-03778-8.

Connectomes across development reveal principles of brain maturation

Immunity. 2021 Aug 3;S1074-7613(21)00292-2. doi: 10.1016/j.immuni.2021.07.006

Selective loss of resident macrophage-derived insulin-like growth factor-1 abolishes adaptive cardiac growth to stress

Cancer Cell. 2021 Aug 9;39(8):1115-1134.e12. doi: 10.1016/j.ccell.2021.06.016.

Binary pan-cancer classes with distinct vulnerabilities defined by pro- or anti-cancer YAP/TEAD activity

Nat Commun. 2021 Aug 18;12(1):5023. doi: 10.1038/s41467-021-25245-8.

DL4-μbeads induce T cell lineage differentiation from stem cells in a stromal cell-free system

Nat Commun. 2021 Aug 17;12(1):4841. doi: 10.1038/s41467-021-24932-w.

ZNF768 links oncogenic RAS to cellular senescence