Canada in Science - September 2023

Kupffer cell-like syncytia replenish resident macrophage function in the fibrotic liver

Journal Issue: Science. 2023 Sep 8;381(6662):eabq5202.

Authors: Peiseler M, Araujo David B, Zindel J, Surewaard BGJ, Lee WY, Heymann F, Nusse Y, Castanheira FVS, Shim R, Guillot A, Bruneau A, Atif J, Perciani C, Ohland C, Ganguli Mukherjee P, Niehrs A, Thuenauer R, Altfeld M, Amrein M, Liu Z, Gordon PMK, McCoy K, Deniset J, MacParland S, Ginhoux F, Tacke F, Kubes P.

PubMed ID: 37676943

Paul Kubes Lab

m6A RNA methylation orchestrates transcriptional dormancy during paused pluripotency

Journal Issue: Nat Cell Biol. 2023 Sep;25(9):1279-1289.

Authors: Collignon E, Cho B, Furlan G, Fothergill-Robinson J, Martin SB, McClymont SA, Ross RL, Limbach PA, Ramalho-Santos M.

PubMed ID: 37696947

Miguel Ramalho-Santos Lab

Meningeal macrophages inhibit chemokine signaling in pre-tumor cells to suppress mouse medulloblastoma initiation

Journal Issue: Dev Cell. 2023 Sep 27:S1534-5807(23)00459-8.

Authors: Pokrajac NT, Tokarew NJA, Gurdita A, Ortin-Martinez A, Wallace VA.

PubMed ID: 37774709

Valerie Wallace Lab

Patient-specific models link neurotransmitter receptor mechanisms with motor and visuospatial axes of Parkinson’s disease

Journal Issue: Nat Commun. 2023 Sep 26;14(1):6009.

Authors: Khan AF, Adewale Q, Lin SJ, Baumeister TR, Zeighami Y, Carbonell F, Palomero-Gallagher N, Iturria-Medina Y.

PubMed ID: 37752107

Yasser Iturria-Medina Lab

Casein kinase 1 and 2 phosphorylate Argonaute proteins to regulate miRNA-mediated gene silencing

Journal Issue: EMBO Rep. 2023 Sep 15:e57250..

Authors: Shah VN, Neumeier J, Huberdeau MQ, Zeitler DM, Bruckmann A, Meister G, Simard MJ.

PubMed ID: 37712432

Martin Simard Lab