{"id":32211,"date":"2025-10-20T14:07:05","date_gmt":"2025-10-20T18:07:05","guid":{"rendered":"https:\/\/www.bloomburton.com\/?p=32211"},"modified":"2026-02-18T18:16:39","modified_gmt":"2026-02-18T22:16:39","slug":"canada-in-science-september-2025","status":"publish","type":"post","link":"https:\/\/www.bloomburton.com\/wordpress\/canada-in-science-september-2025\/","title":{"rendered":"Canada in Science – September 2025"},"content":{"rendered":"\n
\"\"<\/figure>\n\n\n\n
\"\"<\/figure>\n\n\n\n

Genetic suppression features ABHD18 as a Barth syndrome therapeutic target<\/a><\/h4>\n\n\n\n

Journal Issue: <\/strong>Nature. 2025 Sep;645(8082):1029-1038.<\/p>\n\n\n\n

Authors:<\/strong> Masud SN, Srivastava A, Mero P, Echezarreta VS, Anderson E, van Buren L, Wei J, Taylor DT, Farias AG, Mikolajewicz N, Shaw A, Murareanu BM, Lohbihler M, Carney OS, van Heeringen S, Clijsters L, Sizova O, van Ameijde J, Nye F, Habsid A, Nedyalkova L, McDonald L, Simpson C, Wybenga-Groot L, Brown KR, Nho N, Suciu RM, Chan K, Tong AHY, Vaz FM, Evers B, Lesurf R, Papaz T, Nutter LMJ, Protze S, Billmann M, Costanzo M, Andrews BJ, Myers CL, Mital S, Vernon H, Brummelkamp TR, Boone C, Scott IC, Niphakis MJ, Strathdee D, Nijman SMB, Blomen VA, Moffat J.<\/p>\n\n\n\n

PubMed ID:<\/strong> 40903572<\/p>\n\n\n\n

Jason Moffat Lab<\/a><\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

Potentiation of mitochondrial function by mitoDREADD-Gs<\/sub> reverses pharmacological and neurodegenerative cognitive impairment in mice<\/a><\/h4>\n\n\n\n

Journal Issue:<\/strong> Nat Neurosci. 2025 Sep;28(9):1844-1857.<\/p>\n\n\n\n

Authors:<\/strong> Pagano Zottola AC, Mart\u00edn-Jim\u00e9nez R, Lavanco G, Hamel-C\u00f4t\u00e9 G, Ramon-Duaso C, Rodrigues RS, Mariani Y, Khan M, Drago F, Jean S, R\u00edo IB, Jimenez-Blasco D, Ega\u00f1a-Huguet J, Eraso-Pichot A, Beriain S, Cannich A, Vidal-Palencia L, Infantino R, Julio-Kalajzi\u0107 F, Gisquet D, Goncalves A, Al-Younis I, Baussan Y, Duvezin-Caubet S, Devin A, Soria-Gomez E, Puente N, Bola\u00f1os JP, Grandes P, Pouvreau S, Busquets-Garcia A, Marsicano G, Bellocchio L, Hebert-Chatelain E.<\/p>\n\n\n\n

PubMed ID:<\/strong> 40790270<\/p>\n\n\n\n

Etienne Hebert-Chatelain Lab<\/a><\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

Kupffer cells are essential for platelet-mediated thrombopoietin generation in the liver<\/a><\/h4>\n\n\n\n

Journal Issue:<\/strong> Proc Natl Acad Sci U S A. 2025 Sep 23;122(38):e2517319122.<\/p>\n\n\n\n

Authors: <\/strong>Karakas D, Li J, Ma W, Wu XG, Khoury CJ, Masoud M, Hoard B, Liu YJ, Zhu G, Chen J, Sim M, Shen C, L\u00f3pez JA, MacParland SA, Kahr WHA, Ni H.<\/p>\n\n\n\n

PubMed ID:<\/strong> 40961144<\/p>\n\n\n\n

Hey Ni Lab<\/a><\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

A widespread family of molecular chaperones promotes the intracellular stability of type VIIb secretion system-exported toxins<\/a><\/h4>\n\n\n\n

Journal Issue:<\/strong> Proc Natl Acad Sci U S A. 2025 Sep 23;122(38):e2503581122<\/p>\n\n\n\n

Authors: <\/strong>Gkragkopoulou P, Garrett SR, Shah PY, Grebenc DW, Klein TA, Kim Y, Whitney JC.<\/p>\n\n\n\n

PubMed ID: <\/strong>40953262<\/p>\n\n\n\n

John Whitney Lab<\/a><\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

Oncogenic driver mutations underlie the spatial tumour immune landscape of non-small cell lung cancer<\/a><\/h4>\n\n\n\n

Journal Issue:<\/strong> Proc Nat Commun. 2025 Sep 25;16(1):8402.<\/p>\n\n\n\n

Authors:<\/strong> Hartner S, Abolfathi H, Rezanejad M, Liu B, Karimi E, Rogers D, Sorin M, Dor\u00e9 S, Desharnais L, Orain M, Enlow W, Gagn\u00e9 A, Wei Y, Boss\u00e9 Y, Quail DF, Joubert P, Walsh LA.<\/p>\n\n\n\n

PubMed ID:<\/strong> 40998804<\/p>\n\n\n\n

Logan Walsh Lab<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Genetic suppression features ABHD18 as a Barth syndrome therapeutic target Journal Issue: Nature. 2025 Sep;645(8082):1029-1038. Authors: Masud SN, Srivastava A, Mero P, Echezarreta VS, Anderson E, van Buren L, Wei J, Taylor DT, Farias AG, Mikolajewicz N, Shaw A, Murareanu BM, Lohbihler M, Carney OS, van Heeringen S, Clijsters L, Sizova O, van Ameijde J, […]<\/p>\n","protected":false},"author":31,"featured_media":32221,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[122,126],"tags":[],"acf":{"sub_heading":"","background_image":false,"paragraph_after_image":"","date":"","slideshow_module":false,"type_of_background":"Image","image_background":false,"video_medium_background":"","video_mobile_background":"","has_dimmer":false,"dimmer_strength":"0.9"},"_links":{"self":[{"href":"https:\/\/www.bloomburton.com\/wordpress\/wp-json\/wp\/v2\/posts\/32211"}],"collection":[{"href":"https:\/\/www.bloomburton.com\/wordpress\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.bloomburton.com\/wordpress\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.bloomburton.com\/wordpress\/wp-json\/wp\/v2\/users\/31"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bloomburton.com\/wordpress\/wp-json\/wp\/v2\/comments?post=32211"}],"version-history":[{"count":7,"href":"https:\/\/www.bloomburton.com\/wordpress\/wp-json\/wp\/v2\/posts\/32211\/revisions"}],"predecessor-version":[{"id":32311,"href":"https:\/\/www.bloomburton.com\/wordpress\/wp-json\/wp\/v2\/posts\/32211\/revisions\/32311"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.bloomburton.com\/wordpress\/wp-json\/wp\/v2\/media\/32221"}],"wp:attachment":[{"href":"https:\/\/www.bloomburton.com\/wordpress\/wp-json\/wp\/v2\/media?parent=32211"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.bloomburton.com\/wordpress\/wp-json\/wp\/v2\/categories?post=32211"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.bloomburton.com\/wordpress\/wp-json\/wp\/v2\/tags?post=32211"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}