{"id":32236,"date":"2025-12-22T10:00:00","date_gmt":"2025-12-22T14:00:00","guid":{"rendered":"https:\/\/www.bloomburton.com\/?p=32236"},"modified":"2026-02-18T18:18:33","modified_gmt":"2026-02-18T22:18:33","slug":"canada-in-science-november-2025","status":"publish","type":"post","link":"https:\/\/www.bloomburton.com\/wordpress\/canada-in-science-november-2025\/","title":{"rendered":"Canada In Science – November 2025"},"content":{"rendered":"\n
\"\"<\/figure>\n\n\n\n
\"\"<\/figure>\n\n\n\n

Mucosal viral infection elicits long-lived IgA responses via type 1 follicular helper T cells<\/a><\/h4>\n\n\n\n

Journal Issue: <\/strong>Cell. 2025 Nov 26;188(24):6774-6790.e21. <\/p>\n\n\n\n

Authors: <\/strong>Haniuda K, Edner NM, Makita Y, Appiah S, Watts TH, Wu GF, Dileepan T, Gommerman JL. <\/p>\n\n\n\n

PubMed ID:<\/strong> 41253146<\/p>\n\n\n\n

Jennifer Gommerman Lab<\/a><\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

Budigalimab, an anti-PD-1 inhibitor, for people living with HIV-1: a randomized, placebo-controlled phase 1b study<\/a><\/h4>\n\n\n\n

Journal Issue:<\/strong> Nat Med. 2025 Nov;31(11):3879-3888. <\/p>\n\n\n\n

Authors:<\/strong> Ramgopal MN, Lalezari JP, Pires Dos Santos AG, Krishnan P, Vaidya TR, Zhou F, Betman H, Dorr P, Mostafa NM, Alcaide ML, Felizarta F, Routy JP. <\/p>\n\n\n\n

PubMed ID:<\/strong> 41094034<\/p>\n\n\n\n

Jean-Pierre Routy Lab<\/a><\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

Epigenetic alterations facilitate transcriptional and translational programs in hypoxia<\/a><\/h4>\n\n\n\n

Journal Issue:<\/strong> Nat Cell Biol. 2025 Nov;27(11):1965-1981.<\/p>\n\n\n\n

Authors:<\/strong> Watt K, Dauber B, Szkop KJ, Lee L, Jovanovic P, Chen S, Palia R, Vassalakis JA, Cooper TT, Papadopoli D, Masvidal L, Jewer M, Tandoc K, Plummer H, Lajoie GA, Topisirovic I, Larsson O, Postovit LM. <\/p>\n\n\n\n

PubMed ID:<\/strong> 41102449<\/p>\n\n\n\n

Lynne-Marie Postovit Lab<\/a><\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

Cryo-EM structure of endogenous Pfs230:Pfs48\/45 complex with six antibodies reveals mechanisms of malaria transmission-blocking activity<\/a><\/h4>\n\n\n\n

Journal Issue:<\/strong> Immunity. 2025 Nov 11;58(11):2899-2916.e10.<\/p>\n\n\n\n

Authors: <\/strong>Bekkering ET, Yoo R, Hailemariam S, Heide F, Ivanochko D, Jackman M, Proellochs NI, Stoter R, van Gemert GJ, Maeda A, Yuguchi T, Wanders OT, van Daalen RC, Inklaar MR, Andrade CM, Jansen PWTC, Vermeulen M, Bousema T, Takashima E, Rubinstein JL, Kooij TWA, Jore MM, Julien JP. <\/p>\n\n\n\n

PubMed ID: <\/strong>41072404<\/p>\n\n\n\n

Jean-Philippe Julien Lab<\/a><\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

CDK12 inhibition reveals melanoma dependence on the RUNX1\/CBF\u03b2 complex for genomic stability<\/a><\/h4>\n\n\n\n

Journal Issue:<\/strong> Cell Rep. 2025 Nov 25;44(11):116495.<\/p>\n\n\n\n

Authors:<\/strong> Boucher J, Houles T, Berliocchi E, Lavoie G, MacLeod G, Saba-El-Leil MK, Angers S, Meloche S, Roux PP.<\/p>\n\n\n\n

PubMed ID:<\/strong> 41176765<\/p>\n\n\n\n

Philippe Roux Lab<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Mucosal viral infection elicits long-lived IgA responses via type 1 follicular helper T cells Journal Issue: Cell. 2025 Nov 26;188(24):6774-6790.e21.  Authors: Haniuda K, Edner NM, Makita Y, Appiah S, Watts TH, Wu GF, Dileepan T, Gommerman JL.  PubMed ID: 41253146 Jennifer Gommerman Lab Budigalimab, an anti-PD-1 inhibitor, for people living with HIV-1: a randomized, placebo-controlled […]<\/p>\n","protected":false},"author":31,"featured_media":32237,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[122,126],"tags":[],"acf":{"sub_heading":"","background_image":false,"paragraph_after_image":"","date":"","slideshow_module":false,"type_of_background":"Image","image_background":false,"video_medium_background":"","video_mobile_background":"","has_dimmer":false,"dimmer_strength":"0.9"},"_links":{"self":[{"href":"https:\/\/www.bloomburton.com\/wordpress\/wp-json\/wp\/v2\/posts\/32236"}],"collection":[{"href":"https:\/\/www.bloomburton.com\/wordpress\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.bloomburton.com\/wordpress\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.bloomburton.com\/wordpress\/wp-json\/wp\/v2\/users\/31"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bloomburton.com\/wordpress\/wp-json\/wp\/v2\/comments?post=32236"}],"version-history":[{"count":5,"href":"https:\/\/www.bloomburton.com\/wordpress\/wp-json\/wp\/v2\/posts\/32236\/revisions"}],"predecessor-version":[{"id":32307,"href":"https:\/\/www.bloomburton.com\/wordpress\/wp-json\/wp\/v2\/posts\/32236\/revisions\/32307"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.bloomburton.com\/wordpress\/wp-json\/wp\/v2\/media\/32237"}],"wp:attachment":[{"href":"https:\/\/www.bloomburton.com\/wordpress\/wp-json\/wp\/v2\/media?parent=32236"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.bloomburton.com\/wordpress\/wp-json\/wp\/v2\/categories?post=32236"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.bloomburton.com\/wordpress\/wp-json\/wp\/v2\/tags?post=32236"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}