October 20, 2025
Canada in Science - September 2025
Genetic suppression features ABHD18 as a Barth syndrome therapeutic target
Journal Issue: Nature. 2025 Sep;645(8082):1029-1038.
Authors: Masud SN, Srivastava A, Mero P, Echezarreta VS, Anderson E, van Buren L, Wei J, Taylor DT, Farias AG, Mikolajewicz N, Shaw A, Murareanu BM, Lohbihler M, Carney OS, van Heeringen S, Clijsters L, Sizova O, van Ameijde J, Nye F, Habsid A, Nedyalkova L, McDonald L, Simpson C, Wybenga-Groot L, Brown KR, Nho N, Suciu RM, Chan K, Tong AHY, Vaz FM, Evers B, Lesurf R, Papaz T, Nutter LMJ, Protze S, Billmann M, Costanzo M, Andrews BJ, Myers CL, Mital S, Vernon H, Brummelkamp TR, Boone C, Scott IC, Niphakis MJ, Strathdee D, Nijman SMB, Blomen VA, Moffat J.
PubMed ID: 40903572
Potentiation of mitochondrial function by mitoDREADD-Gs reverses pharmacological and neurodegenerative cognitive impairment in mice
Journal Issue: Nat Neurosci. 2025 Sep;28(9):1844-1857.
Authors: Pagano Zottola AC, Martín-Jiménez R, Lavanco G, Hamel-Côté G, Ramon-Duaso C, Rodrigues RS, Mariani Y, Khan M, Drago F, Jean S, Río IB, Jimenez-Blasco D, Egaña-Huguet J, Eraso-Pichot A, Beriain S, Cannich A, Vidal-Palencia L, Infantino R, Julio-Kalajzić F, Gisquet D, Goncalves A, Al-Younis I, Baussan Y, Duvezin-Caubet S, Devin A, Soria-Gomez E, Puente N, Bolaños JP, Grandes P, Pouvreau S, Busquets-Garcia A, Marsicano G, Bellocchio L, Hebert-Chatelain E.
PubMed ID: 40790270
Kupffer cells are essential for platelet-mediated thrombopoietin generation in the liver
Journal Issue: Proc Natl Acad Sci U S A. 2025 Sep 23;122(38):e2517319122.
Authors: Karakas D, Li J, Ma W, Wu XG, Khoury CJ, Masoud M, Hoard B, Liu YJ, Zhu G, Chen J, Sim M, Shen C, López JA, MacParland SA, Kahr WHA, Ni H.
PubMed ID: 40961144
A widespread family of molecular chaperones promotes the intracellular stability of type VIIb secretion system-exported toxins
Journal Issue: Proc Natl Acad Sci U S A. 2025 Sep 23;122(38):e2503581122
Authors: Gkragkopoulou P, Garrett SR, Shah PY, Grebenc DW, Klein TA, Kim Y, Whitney JC.
PubMed ID: 40953262
Oncogenic driver mutations underlie the spatial tumour immune landscape of non-small cell lung cancer
Journal Issue: Proc Nat Commun. 2025 Sep 25;16(1):8402.
Authors: Hartner S, Abolfathi H, Rezanejad M, Liu B, Karimi E, Rogers D, Sorin M, Doré S, Desharnais L, Orain M, Enlow W, Gagné A, Wei Y, Bossé Y, Quail DF, Joubert P, Walsh LA.
PubMed ID: 40998804
