Canada in Science - August 2025

Ubiquitination of the histone variant mH2A1.2 prevents toxic RAD18 accumulation at a subset of genomic loci upon replication stress

Journal Issue: Mol Cell. 2025 Aug 21;85(16):3023-3040.e10.

Authors: Galloy M, Blondeau A, Vion É, Kim D, Bakker CA, Gaggioli V, Thomas M, Lavoie ÉG, Marois I, Delgado Monterroso AD, Masson JY, Taneja N, Miller KM, Maréchal A, Fradet-Turcotte A.

PubMed ID: 40812313

Amelie Fradet-Turcotte Lab

PALB2 and 53BP1 govern post-resection homologous recombination DNA repair

Journal Issue: Mol Cell. 2025 Aug 7;85(15):2824-2838.e8.

Authors: Wang Y, Coulombe Y, Yueh WT, Conway GD, Milano L, Glass DJ, Thomas M, Rodrigue A, Nacson J, Lu D, Bernhardy AJ, Betsch RG, Russo AI, Elfar GA, Cai KQ, Testa JR, Andrake M, Dunbrack R, Gupta GP, Xia B, Dray E, Masson JY, Johnson N.

PubMed ID: 40749686

Jean-Yves Masson Lab

Amyloid-β-driven Alzheimer’s disease reshapes the colonic immune system in mice

Journal Issue: Cell Rep. 2025 Aug 29:116109. doi: 10.1016/j.celrep.2025.116109

Authors: Makhijani P, Valentino TR, Manwaring-Mueller M, Emani R, Mu WC, Aguirre CG, Tan CR, Rane A, Wilson KA, Kifle A, Chen N, Du H, Wu F, Ng JHY, Ambrose BD, Ashok Kumaar PV, Khan S, Winer S, Wang C, Mortha A, Furman D, Schilling B, Ellerby LM, Rojas OL, Andersen JK, Winer DA.

PubMed ID: 40885186

Olga Rojas Lab

Journal Issue: Cell Rep. 2025 Aug 26;44(9):116190.

Authors: Soleimani S, Li X, Wang BX, Pedersen S, Bruce JP, Eagles J, Liu ZA, Bratman SV, Butler MO, Hansen AR, Bedard PL, Lheureux S, Spreafico A, Razak A, Siu LL, Ohashi PS, Pugh TJ.

PubMed ID: 40875293

Trevor Pugh Lab

ITAF45 is a pervasive trans-acting factor for picornavirus Type II IRES elements

Journal Issue: Proc Natl Acad Sci U S A. 2025 Aug 19;122(33):e2506281122..

Authors: Bellucci MA, Amiri M, Berryman S, Moshari A, Owino CO, Luteijn RD, Tuthill TJ, Svitkin Y, Belsham GJ, van Kuppeveld FJM, Sonenberg N.

PubMed ID: 40789037

Nahum Soneneberg Lab