March 3, 2026
Canada in Science - January 2026
Oxidized phosphatidylcholines deposition drives chronic neurodegeneration in a mouse model of progressive multiple sclerosis via IL-1β signaling
Journal Issue: Nat Neurosci. 2026 Jan;29(1):67-80. doi: 10.1038/s41593-025-02113-y.
Authors: Yu R, Lozinski BM, Seifert A, Ta K, Zandee S, Kaushik DK, Park J, Klement W, Larouche S, Tsimikas S, Witztum JL, McGavern DB, Prat A, Dong Y.
PubMed ID: 41326786
Patterns of hypermutation shape tumorigenesis and immunotherapy response in mismatch-repair-deficient glioma
Journal Issue: Nat Genet. 2026 Jan;58(1):132-142.
Authors: Fernandez NR, Chang Y, Nunes NM, Dimayacyac JR, Levine A, Ringel A, Negm L, Ercan AB, Hess JM, Ahmad O, Lee C, Stengs L, Bianchi V, Edwards M, Doherty S, Chung J, Nobre L, Bennett J, Dodgshun AJ, Jones DTW, Pfister SM, Villani A, Malkin D, Ramaswamy V, Huang A, Bouffet E, Aronson M, Dirks PB, Shlien A, Getz G, Maruvka YE, Ertl-Wagner B, Hawkins C, Das A, Tabori U.
PubMed ID: 41430480
Tunable differentiation of human CD4+ and CD8+ T cells from pluripotent stem cells
Journal Issue: Cell Stem Cell. 2026 Jan 8;33(1):73-90.e14.
Authors: Jones RD, Salim K, Stankiewicz LN, Edgar JM, Leon L, Gillies JK, Murtaza A, Durland LJ, Raval D, Lau C, Taberna TPB, Hsu HH, Zimmerman C, Michaels YS, Rossi FMV, Levings MK, Zandstra PW.
PubMed ID: 41512836
Butyrolactol A enhances caspofungin efficacy via flippase inhibition in drug-resistant fungi
Journal Issue: Cell. 2026 Jan 22;189(2):620-639.e28.
Authors: Chen X, Duan HD, Hoy MJ, Koteva K, Spitzer M, Guitor AK, Puumala E, Fiebig AA, Hu G, Yiu B, Chou S, Bian Z, Choi Y, Guo ABY, Wang W, Sun S, Robbins N, Averette AF, Cook MA, Truant R, MacNeil LT, Brown ED, Kronstad JW, Coombes BK, Cowen LE, Heitman J, Li H, Wright GD.
PubMed ID: 41478284
Environmental enrichment and physical exercise prevent stress-induced social avoidance and blood-brain barrier alterations via Fgf2
Journal Issue: Nat Commun. 2026 Jan 16;17(1):1297.
Authors: Paton SEJ, Solano JL, Cadoret A, Collignon A, Binder LB, Daigle B, Bevilacqua LM, Richer É, Coulombe-Rozon F, Dion-Albert L, Dudek KA; Signature Consortium; Lebel M, Ménard C.
PubMed ID: 41545369
