Canada in Science - July 2025

Prophages block cell surface receptors to preserve their viral progeny

Journal Issue: Nature. 2025 Jul 16. doi: 10.1038/s41586-025-09260-z.

Authors: Taylor VL, Patel PH, Shah M, Yusuf A, Burk CM, Sztanko KM, Gitai Z, Davidson AR, Koch MD, Maxwell KL.

PubMed ID: 40670790

Karen Maxwell Lab

ROS transfer at peroxisome-mitochondria contact regulates mitochondrial redox

Journal Issue: Science. 2025 Jul 10;389(6756):157-162. doi: 10.1126/science.adn2804.

Authors: DiGiovanni LF, Khroud PK, Carmichael RE, Schrader TA, Gill SK, Germain K, Jomphe RY, Wiesinger C, Boutry M, Kamoshita M, Snider D, Stubbings G, Hua R, Garber N, Hacker C, Rutenberg AD, Melnyk RA, Berger J, Schrader M, Raught B, Kim PK.

PubMed ID: 40638754

Peter K Kim Lab

Concerted changes in Epithelium and Stroma: a multi-scale, multi-omics analysis of progression from Barrett’s Esophagus to adenocarcinoma

Journal Issue: Dev Cell. 2025 Jul 14:S1534-5807(25)00412-5. doi: 10.1016/j.devcel.2025.06.034.

Authors: Strasser MK, Gibbs DL, Gascard P, Bons J, Hickey JW, Pan D, Caruso JA, Wang X, Chen-Tanyolac C, Bai R, Schürch CM, Tan Y, Black S, Chu P, Ozkan A, Basisty N, Sangwan V, Rose J, Shah S, Burton JB, Camilleri-Broet S, Fiset PO, Bertos N, Berube J, Djambazian H, Li R, Oikonomopoulos S, Elliott DRF, Vernovsky S, Shimshoni E, Collyar D, Russell A, Ragoussis J, Stachler MD, Goldenring JR, McDonald SAC, Ingber DE, Schilling B, Nolan GP, Tlsty TD, Huang S, Ferri LE.

PubMed ID: 40695287

Lorenzo Ferri Lab

A genome-wide in vivo CRISPR activation screen identifies BACE1 as a therapeutic vulnerability of lung cancer brain metastasis

Journal Issue: Sci Transl Med. 2025 Jul 2;17(805):eadu2459. doi: 10.1126/scitranslmed.adu2459.

Authors: Chafe SC, Zhai K, Aghaei N, Miletic P, Huang Z, Brown KR, Mobilio D, Young D, Suk Y, Grewal S, McKenna D, Alizada Z, Kieliszek AM, Lam FC, Escudero L, Huang Q, Huebner A, Lu J, Ang P, Anand A, Custers S, Apel E, Slassi S, Brakel B, Kim J, Liu JKC, Bassey-Archibong BI, Abdo R, Shargall Y, Lu JQ, Cutz JC, Zhang Q, Li SS, Venugopal C, Hynds RE, Dufour A, Moffat J, Swanton C, Bao S, Singh SK.

PubMed ID: 40601773

Sheila Singh Lab