Canada in Science - March 2025

Plasticity of the mammalian integrated stress response

Journal Issue: Nature. 2025 Mar 26. doi: 10.1038/s41586-025-08794-6.

Authors: Chen CW, Papadopoli D, Szkop KJ, Guan BJ, Alzahrani M, Wu J, Jobava R, Asraf MM, Krokowski D, Vourekas A, Merrick WC, Komar AA, Koromilas AE, Gorospe M, Payea MJ, Wang F, Clayton BLL, Tesar PJ, Schaffer A, Miron A, Bederman I, Jankowsky E, Vogel C, Valášek LS, Dinman JD, Zhang Y, Tirosh B, Larsson O, Topisirovic I, Hatzoglou M.

PubMed ID: 40140574

Ivan Topisirovic Lab

A broad-spectrum lasso peptide antibiotic targeting the bacterial ribosome

Journal Issue: Nature. 2025 Mar 26. doi: 10.1038/s41586-025-08723-7.

Authors: Jangra M, Travin DY, Aleksandrova EV, Kaur M, Darwish L, Koteva K, Klepacki D, Wang W, Tiffany M, Sokaribo A, Coombes BK, Vázquez-Laslop N, Polikanov YS, Mankin AS, Wright GD.

PubMed ID: 40140562

Gerard D Wright Lab

GluA2-containing AMPA receptors form a continuum of Ca2+-permeable channels

Journal Issue: Nature. 2025 Mar 19. doi: 10.1038/s41586-025-08736-2.

Authors: Miguez-Cabello F, Wang XT, Yan Y, Brake N, Alexander RPD, Perozzo AM, Khadra A, Bowie D.

PubMed ID: 40108453

Derek Bowie Lab

The landscape of N6-methyladenosine in localized primary prostate cancer

Journal Issue: Nat Genet. 2025 Mar 24. doi: 10.1038/s41588-025-02128-y.

Authors: Xu X, Zhu H, Hugh-White R, Livingstone J, Eng S, Zeltser N, Wang Y, Pajdzik K, Chen S, Houlahan KE, Luo W, Liu S, Xu X, Sheng M, Guo WY, Arbet J, Song Y, Wang M, Zeng Y, Wang S, Zhu G, Gao T, Chen W, Ci X, Xu W, Xu K, Orain M, Picard V, Hovington H, Bergeron A, Lacombe L, Têtu B, Fradet Y, Lupien M, Wei GH, Koritzinsky M, Bristow RG, Fleshner NE, Wu X, Shao Y, He C, Berlin A, van der Kwast T, Leong H, Boutros PC, He HH.

PubMed ID: 40128621

Housheng Hansen He Lab