July 12, 2026
Canada in Science - June 2026
A natural depsipeptide antibiotic binds the E-site of the bacterial ribosome
Journal Issue: Nature. 2026 Jun 3. doi: 10.1038/s41586-026-10589-2.
Authors: Kaur M, Travin DY, Berger MJ, Jangra M, Morici M, Safdari HA, Klepacki D, Wang W, Cook M, Chou S, Guitor AK, Koteva K, Xu M, Ejim L, Fiebig A, Yousefi Y, Coombes BK, Macneil L, Vázquez-Laslop N, Mankin AS, Wilson DN, Wright GD.
PubMed ID: 42236948
Systematic discovery of pathogen effector functions across human pathogens and pathways
Journal Issue: Cell. 2026 Jun 30:S0092-8674(26)00704-X.
Authors: Pachano T, Leng H, Dugied G, Tribble T, Loubiere V, Lee Y, Rauh F, Manon V, Yuan K, Nurtanto J, Schleiffer A, Young V, Weller B, Lyons EA, Hass MR, Kottyan LC, Weirauch MT, Fuxman Bass JI, Newton HJ, Ensminger AW, Falter-Braun P, Chen J, Schramek D, Stark A, Taipale M.
PubMed ID: 42379168
H3K27me3 spreading organizes canonical PRC1 chromatin architecture to regulate developmental programs
Journal Issue: Nat Genet. 2026 Jun;58(6):1368-1382.
Authors: Krug B, Hu B, Chen H, Negrón-Lomas C, Chen X, El Mouatani A, Gretarsson KH, Ptack A, Deshmukh S, Kabir N, Jawhar W, Andrade AF, Jabbour E, Harutyunyan AS, Wang X, Taylor R, Lee JJY, Hulswit M, Faury D, Russo C, Xu X, Yang J, Baguette A, Dahl NA, Weil AG, Ellezam B, Dali R, Blanchette M, Wilson K, Garcia BA, Soni RK, Gallo M, Taylor MD, Kleinman CL, Majewski J, Jabado N, Lu C.
PubMed ID: 42151415
Integrated stress response couples mitochondrial fitness with lineage reprogramming to drive cancer evolution
Journal Issue: Nat Cell Biol. 2026 Jun 15. doi: 10.1038/s41556-026-01991-z.
Authors: Diao S, Zou JY, Wang S, Chan JE, Kortlever RM, Poulain N, Ghaddar N, Kim H, Evan GI, Koumenis C, Hatzoglou M, Walter P, Sonenberg N, Le Quesne J, Tammela T, Koromilas AE.
PubMed ID: 42298057
DMD-Null mice exhibit severe muscle weakness, impaired regeneration, and deficient satellite cell function
Journal Issue: Proc Natl Acad Sci U S A. 2026 Jun 23;123(25):e2606703123.
Authors: Wilton-Clark H, Shah MNA, Leckie J, Hernandez Rodriguez S, Al-Aghbari A, Zhabyeyev P, Maruyama R, Aoki Y, Oudit GY, Yokota T.
PubMed ID: 42301789
