Canada in Science - September & October 2026

An expanded codebook of human transcription factor DNA-binding specificity

Journal: Nature. 2026 Sep;657(8130):275-283. doi: 10.1038/s41586-026-10798-9

Authors: Jolma A, Laverty KU, Fathi A, Yang AWH, Yellan I, Vorontsov IE, Gralak AJ, Kribelbauer-Swietek JF, Inukai S, Razavi R, Albu M, Brechalov A, Patel ZM, Nozdrin V, Meshcheryakov G, Buyan A, Kozin I, Abramov S, Boytsov A; Codebook Consortium; Morris Q, Weirauch MT, Fornes O, Makeev VJ, Grau J, Grosse I, Bucher P, Deplancke B, Kulakovskiy IV, Hughes TR.

PubMed ID: 42557334

Timothy Hughes Lab

Histone readers MLLT1 and MLLT3 concentrate AID to confer locus specificity

Journal: Nature. 2026 Sep 30. doi: 10.1038/s41586-026-11087-1.

Authors: Seija N, Gannon S, Häfner KA, Gemeinhardt TM, Ridani J, Alvarez D, Provencher M, Subramani PG, Poitras C, Piskor EM, Möröy T, Vonniessen N, Mazer B, Navarrette MA, Francis NJ, Robert F, Di Noia JM.

PubMed ID: 42816610

Javier di Noia Lab

Prefibrotic bone marrow microenvironment is a hallmark of clonal hematopoiesis

Journal: Nat Immunol. 2026 Sep 30. doi: 10.1038/s41590-026-02668-3.

Authors: Aguilar-Navarro AG, Edun G, Gower M, Kant J, Li X, Yang D, Nader M, Fernandez M, Jahangiri S, Tsao E, Joshi P, Kossinna P, Caloren LC, Davey JR, Zywiel MG, Suderman RP, Kapoor AI, Akens MK, Changoor A, Woo M, Stanley RF, Young KA, Tran C, Sotov V, Wang BX, Abelson S, Abdel-Wahab O, Naik S, Trowbridge JJ, Vanner R, Hope KJ, Tsui H, Gaiti F, Tikhonova AN.

PubMed ID: 42816584

Anastasia Tikhonova Lab

Genetic landscape of an in vivo protein interactome

Journal: Nat Genet. 2026 Sep 21. doi: 10.1038/s41588-026-02747-z.

Authors: Besse S, Sakaguchi T, Gauthier L, Sahaf Z, Ravindran R, Gonzalez L, Castellanos-Girouard X, Clermont C, Koçatug N, Péloquin O, Matta C, Hussin JG, Michnick SW, Serohijos AWR.

PubMed ID: 42768123

Adrian Serohijos Lab

Nuclear body assembly by a viral repeat RNA promotes Kaposi’s sarcoma-associated herpesvirus gene expression

Journal: Mol Cell. 2026 Oct 1;86(19):3882-3896.e3. doi: 10.1016/j.molcel.2026.08.023. Epub 2026 Sep 17.

Authors: Kleer M, Mulloy RP, Bui-Marinos MP, Johnston MJ, Khan MF, Schriemer DC, Corcoran JA.

PubMed ID: 42748910

Jennifer Corcoran Lab

A microexon regulatory code reveals autism-linked genetic variation

Journal: Nature. 2026 Oct 14. doi: 10.1038/s41586-026-11119-w

Authors: Parada GE, Bretschneider H, Li JD, Fine JL, Dupas SJ, Ellis JD, Braunschweig U, Bonnal S, Dalal T, Engchuan W, Zarrei M, Wei W, Zafar N, Hemberg M, Attisano L, Ellis J, Irimia M, Wainberg M, Trost B, Scherer SW, Morris QD, Blencowe BJ.

PubMed ID: 42875502

Benjamin Blencowe Lab

Periventricular gradient pathology is linked to ependymal reactivity and cell adhesion disruption in multiple sclerosis

Journal: Nat Neurosci. 2026 Oct 15. doi: 10.1038/s41593-026-02461-3.

Authors: Groh AMR, Afanasiev E, Thevakumaran R, Creeggan F, Callahan-Martin L, Bigotte M, Yaqubi M, Gertsvolf J, Pei J, Wu H, de Vos J, Aalders MCG, Zandee S, Prat A, Rudko DA, Stratton JA.

PubMed ID: 42881221

Jo Anne Stratton Lab

A heritability-optimized method for functional prioritization of rare coding variants in complex traits

Journal: Nat Genet. 2026 Oct;58(10):2502-2513. doi: 10.1038/s41588-026-02766-w.

Authors: Pang K, Pathan N, Le A, Man A, Graf J, Li Y, da Rocha GL, Shemesh E, Grafodatskaya D, Chong MR, Paré G.

PubMed ID: 42834204

Guillaume Paré Lab

Motile vesicles (MoVes) are a cancer cell migration-associated extracellular vesicle population

Journal: Nat Cell Biol. 2026 Oct 28. doi: 10.1038/s41556-026-02097-2.

Authors: Tsering T, Nadeau A, Ghasemi M, Mousovich-Neto F, Tobias G, Chen Y, Kienzle L, Dickinson K, Douanne N, Serganova I, Zappasodi R, Matei I, Lyden D, Burnier JV.

PubMed ID: 42951907

Julia Burnier Lab