Canada in Science - July 2026

Prior therapy defines mutation profiles in childhood cancer at relapse

Journal Issue: Nature. 2026 Jul 22. doi: 10.1038/s41586-026-10803-1.

Authors: Layeghifard M, Díaz-Gay M, Bergstrom EN, Mahendralingam MJ, Light N, Blay S, Nash JO, Anderson ND, Au JN, Davidson S, Ballester PL, Wen T, Daud SK, Edward LM, Ashiqul Islam SM, Khandekar A, Otlu B, Brunga L, Hammad R, Nassif S, Thacker NH, Feltham T, Fuentes-Bolanos NA, Wong-Erasmus M, Levine MF, Miller KE, Shukla NN, Kinnaman MD, Glodzik D, Portwine C, Millson S, Zorzi AP, Mikhail M, Fernandez CV, Wheaton L, Gundem G, Kung AL, Tabori U, Mayoh C, Papaemmanuil E, Cowley MJ, Malkin D, Villani A, Alexandrov LB, Shlien A.

PubMed ID: 42486975

Adam Shlien Lab

The genetic architecture of fibromyalgia across 2.5 million individuals

Journal Issue: Nat Med. Jul 28. doi: 10.1038/s41591-026-04492-6.

Authors: Kerrebijn I, Bjornsdottir G, Arbabi K, Urpa L, Haapaniemi H, Thorleifsson G, Stefansdottir L, Frangakis S, Valliere J, Kunorozva L, Abner E, Ji C, Kangur M, Aagaard B, Bliddal H, Brunak S, Bruun MT, Didriksen M, Erikstrup C, Finer S, Geirsson AJ, Gudbjartsson DF, Hansen TF, van Heel D, Jonsdottir I, Knight S, Knowlton KU, Mikkelsen C, Nadauld LD, Olafsdottir TA, Ostrowski SR, Pedersen OBV, Saevarsdottir S, Skuladottir AT, Sørensen E, Stefansson H, Sulem P, Sveinsson OA, Thorlacius GE, Thorsteinsdottir U, Ullum H, Vikingsson A, Werge TM; Chronic Pain Genomics Consortium; FinnGen; DBDS Genomic Consortium; Estonian Biobank Research Team; Genes & Health Research Team; Saxena R, Stefansson K, Brummett CM, Glintborg B, Clauw DJ, Thorgeirsson TE, Williams FMK, Sinnott-Armstrong N, Ollila HM, Wainberg M.

PubMed ID: 42521817

Michael Wainberg Lab

Endothelial cell-intrinsic NOD2 signaling regulates the intestinal immune response through the generation of effector and memory T cells

Journal Issue: Nat Immunol. 2026 Jul 20. doi: 10.1038/s41590-026-02595-3.

Authors: Tsankov BK, Denney M, Ahn JSY, Carr C, Nathan N, Tsang DKL, Bayer G, Baerg L, Luchak A, Mukherjee T, Tam E, Samman B, Gommerman JL, Girardin SE, Philpott DJ.

PubMed ID: 42477058

Dana Philpott / Stephen Girardin Labs

Murine autoantigen-specific type 1 regulatory T cells promote oligodendrogenesis through amphiregulin-EGFR signaling

Journal Issue: Sci Transl Med. 2026 Jul 15;18(858):eaef2269.

Authors: Clarke R, Rayatpour A, Garnica J, Lozinski BM, Lee J, Mohapatra S, Yamanouchi J, Moro J, Mondal D, Morch MT, Khakpour M, Murray CJ, Volk C, Tremblay ME, Serra P, Yang Y, Yong VW, Santamaria P.

PubMed ID: 42455897

Pere Santamaria Lab