Canada in Science - February 2025

Brain pericytes and perivascular fibroblasts are stromal progenitors with dual functions in cerebrovascular regeneration after stroke

Journal Issue: Nat Neurosci. 2025 Mar;28(3):517-535. doi: 10.1038/s41593-025-01872-y. Epub 2025 Feb 17.

Authors: Bernier LP, Hefendehl JK, Scott RW, Tung LW, Lewis CA, Soliman H, Simm S, Dissing-Olesen L, Hofmann J, Guo D, DeMeglio M, Rossi FM, Underhill TM, MacVicar BA.

PubMed ID: 39962273

Brian MacVicar Lab

Astrocytic cannabinoid receptor 1 promotes resilience by dampening stress-induced blood-brain barrier alterations

Journal Issue: Nat Neurosci. 2025 Feb 27. doi: 10.1038/s41593-025-01891-9.

Authors: Dudek KA, Paton SEJ, Binder LB, Collignon A, Dion-Albert L, Cadoret A, Lebel M, Lavoie O, Bouchard J, Kaufmann FN, Clavet-Fournier V, Manca C, Guzmán M, Campbell M, Turecki G, Mechawar N, Flamand N, Lavoie-Cardinal F, Silvestri C, Di Marzo V, Menard C.

PubMed ID: 40016352

Caroline Menard Lab

Quantifying metabolites using structure-switching aptamers coupled to DNA sequencing

Journal Issue: Nat Biotechnol. 2025 Feb 4. doi: 10.1038/s41587-025-02554-7.

Authors: Tan JH, Fraser AG.

PubMed ID: 39905266

Andrew Fraser Lab

Cross-kingdom-mediated detection of intestinal protozoa through NLRP6

Journal Issue: Cell Host Microbe. 2025 Feb 26:S1931-3128(25)00056-3. doi: 10.1016/j.chom.2025.02.008.

Authors: Winsor NJ, Bayer G, Singh O, Chan JK, Li LY, Lieng BY, Foerster E, Popovic A, Tsankov BK, Maughan H, Lemire P, Tam E, Streutker C, Chen L, Heaver SL, Ley RE, Parkinson J, Montenegro-Burke JR, Birchenough GMH, Philpott DJ, Girardin SE.

PubMed ID: 40043701

Stephen Girardin Lab

Cryptic genetic variation shapes the fate of gene duplicates in a protein interaction network

Journal Issue: Nat Commun. 2025 Feb 11;16(1):1530. doi: 10.1038/s41467-025-56597-0.

Authors: Dibyachintan S, Dubé AK, Bradley D, Lemieux P, Dionne U, Landry CR.

PubMed ID: 339934115

Christian Landry Lab