Canada in Science - April 2025

Metformin reduces the competitive advantage of Dnmt3a^R878H HSPCs

Journal Issue: Nature. 2025 Apr 16. doi: 10.1038/s41586-025-08871-w

Authors: Hosseini M, Voisin V, Chegini A, Varesi A, Cathelin S, Ayyathan DM, Liu ACH, Yang Y, Wang V, Maher A, Grignano E, Reisz JA, D’Alessandro A, Young K, Wu Y, Fiumara M, Ferrari S, Naldini L, Gaiti F, Pai S, Egan G, Schimmer AD, Bader GD, Dick JE, Xie SZ, Trowbridge JJ, Chan SM.

PubMed ID: 40240595

Steven Chan Lab

A type 1 immune-stromal cell network mediates disease tolerance against intestinal infection

Journal Issue: Cell. 2025 Apr 19:S0092-8674(25)00395-2.

Authors: Westfall S, Gentile ME, Olsen TM, Karo-Atar D, Bogza A, Röstel F, Pardy RD, Mandato G, Fontes G, Herbert D, Melichar HJ, Abadie V, Richer MJ, Vinh DC, Koenig JFE, Harrison OJ, Divangahi M, Weis S, Gregorieff A, King IL.

PubMed ID: 40267906

Irah King Lab

GDF15 links adipose tissue lipolysis with anxiety

Journal Issue: Nat Metab. 2025 Apr 15. doi: 10.1038/s42255-025-01264-3.

Authors: Townsend LK, Wang D, Knuth CM, Fayyazi R, Mohammad A, Becker LJ, Tsakiridis EE, Desjardins EM, Patel Z, Valvano CM, Lu J, Payne AE, Itua O, Medak KD, Marko DM, Schertzer JD, Wright DC, Beaudette SM, Morrison KM, Carpentier AC, Blondin DP, MacPherson REK, McCall JG, Jeschke MG, Steinberg GR.

PubMed ID: 40234625

Gregory Steinberg Lab

Apolipoprotein-A1 transports and regulates MMP2 in the blood

Journal Issue: Nat Commun. 2025 Apr 22;16(1):3752.

Authors: Sarker H, Panigrahi R, Lopez-Campistrous A, McMullen T, Reyes K, Anderson E, Krishnan V, Hernandez-Anzaldo S, Zheng XL, Glover JNM, Hardy E, Fernandez-Patron C.

PubMed ID: 40263360

Carlos Fernandez-Patron Lab