Canada in Science - June 2025

A disordered linker in the Polycomb protein Polyhomeotic tunes phase separation and oligomerization

Journal Issue: Mol Cell. 2025 Jun 5;85(11):2128-2146.e15.

Authors: Gemeinhardt TM, Regy RM, Phan TM, Pal N, Sharma J, Senkovich O, Mendiola AJ, Ledterman HJ, Henrickson A, Lopes D, Kapoor U, Bihani A, Sihou D, Kim YC, Jeruzalmi D, Demeler B, Kim CA, Mittal J, Francis NJ.

PubMed ID: 40441156

Nicole Francis Lab

A fungal-derived adjuvant amplifies the antitumoral potency of Bacillus Calmette-Guérin via reprogramming granulopoiesis

Journal Issue: Immunity. 2025 Jun 19:S1074-7613(25)00247-X.

Authors: Jurado LF, Daman AW, Li Z, Ross VMS, Nikolaou K, Tran KA, Loutochin O, McPherson VA, Prével R, Tarancón R, Couto K, Pernet E, Khan N, Cheong JG, Ramaiah R, Ketavarapu M, Kaufmann E, Glickman MS, Thanabalasuriar A, Josefowicz SZ, Divangahi M.

PubMed ID: 40555239

Maziar Divangahi Lab

Podocyte YAP and TAZ hyperactivation drives glomerular epithelial proliferative diseases in mice and humans

Journal Issue: Science. 2025 May 1:eadk7633.

Authors: He X, Ballestas ER, Zeng L, Zhang T, McEvoy CM, Misra PS, Ki V, Apostol A, Wong JS, Meliambro K, Ray J, De Cos M, Melica ME, Romagnani P, Feng Y, Krizova A, How I, Rosales IA, Colvin RB, He JC, Campbell KN, Yuen DA.

PubMed ID: 40560997

Darren Yuen Lab

Journal Issue: Proc Natl Acad Sci U S A. 2025 Jun 24;122(25):e2506043122.

Authors: Oppedisano A, Bailey ML, Kumar A, O’Neil NJ, Stirling PC, Hieter P.

PubMed ID: 40531874

Philip Hieter Lab

CDADC1 is a vertebrate-specific dCTP deaminase that metabolizes gemcitabine and decitabine to prevent cellular toxicity

Journal Issue: Proc Natl Acad Sci U S A. 2025 Jun 17;122(24):e2424409122.

Authors: Rodriguez MM, Chatterjee D, Guerry J, Patenaude AM, Cohen CCH, Bois T, Larouche A, Ferreira SR, Bertomeu T, Chatr-Aryamontri A, Zhang L, Mader S, Nislow C, St-Jean G, Guindon Y, Zahn A, Di Noia JM.

PubMed ID: 40504152

Javier Di Noia Lab