Canada in Science - May 2025

BRAF oncogenic mutants evade autoinhibition through a common mechanism

Journal Issue: Science. 2025 May 29;388(6750):eadp2742.

Authors: Lavoie H, Jin T, Lajoie D, Decossas M, Gendron P, Wang B, Filandr F, Sahmi M, Hwa Jo C, Weber S, Arseneault G, Tripathy S, Beaulieu P, Schuetz DA, Schriemer DC, Marinier A, Rice WJ, Maisonneuve P, Therrien M.

PubMed ID: 40440367

Marc Therrien Lab

Engineering TCR-controlled fuzzy logic into CAR T cells enhances therapeutic specificity

Journal Issue: Cell. 2025 May 1;188(9):2372-2389.e35.

Authors: Kondo T, Bourassa FXP, Achar S, DuSold J, Céspedes PF, Ando M, Dwivedi A, Moraly J, Chien C, Majdoul S, Kenet AL, Wahlsten M, Kvalvaag A, Jenkins E, Kim SP, Ade CM, Yu Z, Gaud G, Davila M, Love P, Yang JC, Dustin ML, Altan-Bonnet G, François P, Taylor N.

PubMed ID: 40220754

Paul Francois Lab

Bespoke plant glycoconjugates for gut microbiota-mediated drug targeting

Journal Issue: Science. 2025 May 1:eadk7633.

Authors: Ma WJ, Wang C, Kothandapani J, Luzentales-Simpson M, Menzies SC, Bescucci DM, Lange ME, Fraser ASC, Gusse JF, House KE, Moote PE, Xing X, Grondin JM, Hui BW, Clarke ST, Shelton TG, Haskey N, Gibson DL, Martens EC, Abbott DW, Inglis GD, Sly LM, Brumer H.

PubMed ID: 40310938

Harry Brumer Lab

Endothelial dysfunction drives atherosclerotic plaque macrophage-dependent abdominal aortic aneurysm formation

Journal Issue: Nat Immunol. 2025 May;26(5):706-721.

Authors: Thayaparan D, Emoto T, Khan AB, Besla R, Hamidzada H, El-Maklizi M, Sivasubramaniyam T, Vohra S, Hagerman A, Nejat S, Needham-Robbins CE, Wang T, Lindquist M, Botts SR, Schroer SA, Taniguchi M, Inoue T, Yamanaka K, Cui H, Al-Chami E, Zhang H, Althagafi MG, Michalski A, McGrath JJC, Cass SP, Luong D, Suzuki Y, Li A, Abow A, Heo R, Pacheco S, Chen E, Chiu F, Byrne J, Furuyashiki T, Husain M, Libby P, Okada K, Howe KL, Heximer SP, Yamashita T, Wang B, Rubin BB, Cybulsky MI, Roy J, Williams JW, Crome SQ, Epelman S, Hirata KI, Stampfli MR, Robbins CS.

PubMed ID: 40263614

Clinton Robbins Lab

Liposomal lipid nanoparticles for extrahepatic delivery of mRNA

Journal Issue: Nat Commun. 2025 May 3;16(1):4135.

Authors: Cheng MHY, Zhang Y, Fox K, Leung J, Strong C, Kang E, Chen Y, Tong M, Bommadevara H, Jan E, Ip OYL, Rodríguez-Rodríguez C, Saatchi K, Häfeli UO, Abdolahzadeh A, Witzigmann D, Cullis PR.

PubMed ID: 40319025

Pieter Cullis Lab