Canada In Science - November 2025

Mucosal viral infection elicits long-lived IgA responses via type 1 follicular helper T cells

Journal Issue: Cell. 2025 Nov 26;188(24):6774-6790.e21.

Authors: Haniuda K, Edner NM, Makita Y, Appiah S, Watts TH, Wu GF, Dileepan T, Gommerman JL.

PubMed ID: 41253146

Jennifer Gommerman Lab

Budigalimab, an anti-PD-1 inhibitor, for people living with HIV-1: a randomized, placebo-controlled phase 1b study

Journal Issue: Nat Med. 2025 Nov;31(11):3879-3888.

Authors: Ramgopal MN, Lalezari JP, Pires Dos Santos AG, Krishnan P, Vaidya TR, Zhou F, Betman H, Dorr P, Mostafa NM, Alcaide ML, Felizarta F, Routy JP.

PubMed ID: 41094034

Jean-Pierre Routy Lab

Epigenetic alterations facilitate transcriptional and translational programs in hypoxia

Journal Issue: Nat Cell Biol. 2025 Nov;27(11):1965-1981.

Authors: Watt K, Dauber B, Szkop KJ, Lee L, Jovanovic P, Chen S, Palia R, Vassalakis JA, Cooper TT, Papadopoli D, Masvidal L, Jewer M, Tandoc K, Plummer H, Lajoie GA, Topisirovic I, Larsson O, Postovit LM.

PubMed ID: 41102449

Lynne-Marie Postovit Lab

Cryo-EM structure of endogenous Pfs230:Pfs48/45 complex with six antibodies reveals mechanisms of malaria transmission-blocking activity

Journal Issue: Immunity. 2025 Nov 11;58(11):2899-2916.e10.

Authors: Bekkering ET, Yoo R, Hailemariam S, Heide F, Ivanochko D, Jackman M, Proellochs NI, Stoter R, van Gemert GJ, Maeda A, Yuguchi T, Wanders OT, van Daalen RC, Inklaar MR, Andrade CM, Jansen PWTC, Vermeulen M, Bousema T, Takashima E, Rubinstein JL, Kooij TWA, Jore MM, Julien JP.

PubMed ID: 41072404

Jean-Philippe Julien Lab

CDK12 inhibition reveals melanoma dependence on the RUNX1/CBFβ complex for genomic stability

Journal Issue: Cell Rep. 2025 Nov 25;44(11):116495.

Authors: Boucher J, Houles T, Berliocchi E, Lavoie G, MacLeod G, Saba-El-Leil MK, Angers S, Meloche S, Roux PP.

PubMed ID: 41176765

Philippe Roux Lab