September 21, 2026
Canada in Science - August 2026
Nonviral delivery of chemically modified tRNA rescues nonsense mutations in cystic fibrosis
Journal Issue: Nature. Science. 2026 Aug 27;393(6814):eaeb0054. doi: 10.1126/science.aeb0054.
Authors: Chen J, Zhou M, Dong S, Gong F, Tennakoon R, Seto BY, Chen ZR, Zhou ZP, Pan J, Xu Y, Luozhong S, Macarios CM, Tijaro-Bulla S, Gonska T, Hu J, Cui H, Li B.
PubMed ID: 42658930
Modality-specific neurovascular coupling via layer-segregated arteriole networks
Journal Issue: Science. 2026 Aug 20;393(6813):eaeb5077. doi: 10.1126/science.aeb5077.
Authors: Malescot A, Malheiros-Lima MR, Zana L, Bennett MC, Martineau É, Schmid F, Rungta RL.
PubMed ID: 42623473
GPNMB-directed CAR T cell therapy against MiT/TFE-family fusion-driven solid tumors
Journal Issue: Nat Cancer. 2026 Aug;7(8):1189-1207. doi: 10.1038/s43018-026-01194-3
Authors: Zemp FJ, Breckenridge Z, Song H, Gill GS, Louie TL, Narta K, Liu H, Suh Y, Guignard L, Mandujano-Tinoco EA, Collao N, Pyczek J, Ellestad KK, Curry J, Langley J, John C, Mah LK, Rajwani J, Evseev D, Turk M, Benaoudia S, Alex J, Naumenko V, Manoharan VT, Mehrabadi MK, Smith HA, Gilbert GNY, Gillmor A, Verhey TB, Todesco HM, Osz K, Ahn BY, Bogossian A, Anderson C, Sikdar S, Rukunuddin S, Bismar TA, Heng DYC, Lawson K, Linehan WM, Pedersen H, Gordon PMK, McIntyre JB, MacGregor J, Garzia L, Brodeur-Robb K, DiFrancesco L, Ogilvie T, Schöffski P, Wozniak A, Holt RA, Bell J, Senger DL, Lewis V, Monument M, Khan O, Baudrier L, Billon P, Gabriel V, Biernaskie J, Potts K, Trpkov K, Hay K, Quizi J, Chan J, Saleh R, Henning JW, Prokopishyn NL, Shafey M, Morrissy AS, Mahoney DJ.
PubMed ID: 42387022
Loss of Sox10 prevents tumor initiation in vivo and induces luminal-to-basal reprogramming in Neu+ tumor cells
Journal Issue: Proc Natl Acad Sci U S A 2026 Aug 25;123(34):e2520063123. doi: 10.1073/pnas.2520063123.
Authors: Garland B, Delisle S, Abou-Hamad J, de Souza C, Zuccarini R, Cook DP, Auer RC, Sabourin LA.
PubMed ID: 42627829
Population-scale disease-associated tandem repeat analysis reveals locus and ancestry-specific insights
Journal Issue: Nat Commun. 2026 Aug 6;17(1):9439. doi: 10.1038/s41467-026-75404-y.
Authors: Rajan-Babu IS, Chiu R, Weisburd B, Caglayan I, Birol I, Friedman JM.
PubMed ID: 42686677
