Canada in Science - August 2023

Chemoenzymatic synthesis of genetically-encoded multivalent liquid N-glycan arrays

Journal Issue: Nat Commun. 2023 Aug 28;14(1):5237.

Authors: Lin CL, Sojitra M, Carpenter EJ, Hayhoe ES, Sarkar S, Volker EA, Wang C, Bui DT, Yang L, Klassen JS, Wu P, Macauley MS, Lowary TL, Derda R.

PubMed ID: 37640713

Ratmir Derda Lab

Epigenetic and molecular coordination between HDAC2 and SMAD3-SKI regulates essential brain tumour stem cell characteristics

Journal Issue: Nat Commun. 2023 Aug 19;14(1):5051.

Authors: Bahia RK, Hao X, Hassam R, Cseh O, Bozek DA, Luchman HA, Weiss S.

PubMed ID: 37598220

Samuel Weiss Lab

Astroglial Hmgb1 regulates postnatal astrocyte morphogenesis and cerebrovascular maturation

Journal Issue: Nat Commun. 2023 Aug 16;14(1):4965.

Authors: Freitas-Andrade M, Comin CH, Van Dyken P, Ouellette J, Raman-Nair J, Blakeley N, Liu QY, Leclerc S, Pan Y, Liu Z, Carrier M, Thakur K, Savard A, Rurak GM, Tremblay MÈ, Salmaso N, da F Costa L, Coppola G, Lacoste B.

PubMed ID: 37587100

Baptiste Lacoste Lab

An AlphaFold2 map of the 53BP1 pathway identifies a direct SHLD3-RIF1 interaction critical for shieldin activity

Journal Issue: EMBO Rep. 2023 Aug 3;24(8):e56834.

Authors: Sifri C, Hoeg L, Durocher D, Setiaputra D.

PubMed ID: 37306046

Dan Durocher Lab

Ezh2 promotes mammary tumor initiation through epigenetic regulation of the Wnt and mTORC1 signaling pathways

Journal Issue: Proc Natl Acad Sci U S A. 2023 Aug 15;120(33):e2303010120.

Authors: Liu L, Xiao B, Hirukawa A, Smith HW, Zuo D, Sanguin-Gendreau V, McCaffrey L, Nam AJ, Muller WJ.

PubMed ID: 37549258

William Muller Lab