Canada in Science - December 21, 2021

Double feature showcasing Canadian scientific discoveries in November and December to wrap up the year 2021.

Cell Stem Cell. 2021 Dec 2;28(12):2047-2061.e5.

Ramzy A, Thompson DM, Ward-Hartstonge KA, Ivison S, Cook L, Garcia RV, Loyal J, Kim PTW, Warnock GL, Levings MK, Kieffer TJ.

Implanted pluripotent stem-cell-derived pancreatic endoderm cells secrete glucose-responsive C-peptide in patients with type 1 diabetes

Nat Med. 2021 Nov 15. doi: 10.1038/s41591-021-01576-3.

Sinha S, Rosin NL, Arora R, Labit E, Jaffer A, Cao L, Farias R, Nguyen AP, de Almeida LGN, Dufour A, Bromley A, McDonald B, Gillrie MR, Fritzler MJ, Yipp BG, Biernaskie J.

Dexamethasone modulates immature neutrophils and interferon programming in severe COVID-19

Nat Biomed Eng. 2021 Dec;5(12):1437-1456.

Nguyen L, McCord KA, Bui DT, Bouwman KM, Kitova EN, Elaish M, Kumawat D, Daskhan GC, Tomris I, Han L, Chopra P, Yang TJ, Willows SD, Mason AL, Mahal LK, Lowary TL, West LJ, Hsu SD, Hobman T, Tompkins SM, Boons GJ, de Vries RP, Macauley MS, Klassen JS.

Sialic acid-containing glycolipids mediate binding and viral entry of SARS-CoV-2

PLoS Pathog. 2021 Dec 16;17(12):e1010092

Kim GN, Choi JA, Wu K, Saeedian N, Yang E, Park H, Woo SJ, Lim G, Kim SG, Eo SK, Jeong HW, Kim T, Chang JH, Seo SH, Kim NH, Choi E, Choo S, Lee S, Winterborn A, Li Y, Parham K, Donovan JM, Fenton B, Dikeakos JD, Dekaban GA, Haeryfar SMM, Troyer RM, Arts EJ, Barr SD, Song M, Kang CY.

A vesicular stomatitis virus-based prime-boost vaccination strategy induces potent and protective neutralizing antibodies against SARS-CoV-2

Nature. 2021 Dec;600(7888):324-328.

Feng Y, Li C, Stewart JA, Barbulescu P, Desivo NS, Álvarez-Quilón A, Pezo RC, Perera MLW, Chan K, Tong AHY, Mohamad-Ramshan R, Berru M, Nakib D, Li G, Kardar GA, Carlyle JR, Moffat J, Durocher D, Di Noia JM, Bhagwat AS, Martin A.

FAM72A antagonizes UNG2 to promote mutagenic repair during antibody maturation

Nat Immunol. 2021 Dec;22(12):1524-1537. doi: 10.1038/s41590-021-01060-7.

Snell LM, Xu W, Abd-Rabbo D, Boukhaled G, Guo M, Macleod BL, Elsaesser HJ, Hezaveh K, Alsahafi N, Lukhele S, Nejat S, Prabhakaran R, Epelman S, McGaha TL, Brooks DG.

Dynamic CD4 + T cell heterogeneity defines subset-specific suppression and PD-L1-blockade-driven functional restoration in chronic infection

Nat Biomed Eng. 2021 Dec;5(12):1437-1456.

Noskovicova N, Schuster R, van Putten S, Ezzo M, Koehler A, Boo S, Coelho NM, Griggs D, Ruminski P, McCulloch CA, Hinz B.

Suppression of the fibrotic encapsulation of silicone implants by inhibiting the mechanical activation of pro-fibrotic TGF-β

Proc Natl Acad Sci U S A. 2021 Dec 14;118(50):e2116325118.

Toyama Y, Kay LE.

Probing allosteric interactions in homo-oligomeric molecular machines using solution NMR spectroscopy

Nat Cell Biol. 2021 Dec 6. doi: 10.1038/s41556-021-00798-4.

König T, Nolte H, Aaltonen MJ, Tatsuta T, Krols M, Stroh T, Langer T, McBride HM.

MIROs and DRP1 drive mitochondrial-derived vesicle biogenesis and promote quality control

Proc Natl Acad Sci U S A. 2021 Dec 14;118(50):e2113789118.

Bergeron-Sandoval LP, Kumar S, Heris HK, Chang CLA, Cornell CE, Keller SL, François P, Hendricks AG, Ehrlicher AJ, Pappu RV, Michnick SW.

Endocytic proteins with prion-like domains form viscoelastic condensates that enable membrane remodeling