Canada in Science - February 2023

Deconvolution of clinical variance in CAR-T cell pharmacology and response

Journal Issue: Nat Biotechnol. 2023 Feb 27. doi: 10.1038/s41587-023-01687-x.

Authors: Kirouac DC, Zmurchok C, Deyati A, Sicherman J, Bond C, Zandstra PW.

PubMed ID: 36849828

Peter Zandstra Lab

Neonatal imprinting of alveolar macrophages via neutrophil-derived 12-HETE

Journal Issue: Nature. 2023 Feb;614(7948):530-538.

Authors: Pernet E, Sun S, Sarden N, Gona S, Nguyen A, Khan N, Mawhinney M, Tran KA, Chronopoulos J, Amberkar D, Sadeghi M, Grant A, Wali S, Prevel R, Ding J, Martin JG, Thanabalasuriar A, Yipp BG, Barreiro LB, Divangahi M.

PubMed ID: 36599368

Maziar Divangahi Lab

Loss of C9orf72 perturbs the Ran-GTPase gradient and nucleocytoplasmic transport, generating compositionally diverse Importin β-1 granules

Journal Issue: Cell Rep. 2023 Feb 22;42(3):112134.

Authors: McGoldrick P, Lau A, You Z, Durcan TM, Robertson J.

PubMed ID: 36821445

Janice Robertson Lab

Single-cell spatial landscapes of the lung tumour immune microenvironment

Journal Issue: Nature. 2023 Feb;614(7948):548-554.

Authors: Sorin M, Rezanejad M, Karimi E, Fiset B, Desharnais L, Perus LJM, Milette S, Yu MW, Maritan SM, Doré S, Pichette É, Enlow W, Gagné A, Wei Y, Orain M, Manem VSK, Rayes R, Siegel PM, Camilleri-Broët S, Fiset PO, Desmeules P, Spicer JD, Quail DF, Joubert P, Walsh LA.

PubMed ID: 36725934

Logan Walsh Lab

An HLA-G/SPAG9/STAT3 axis promotes brain metastases

Journal Issue: Proc Natl Acad Sci U S A. 2023 Feb 21;120(8):e2205247120.

Authors: Bassey-Archibong BI, Rajendra Chokshi C, Aghaei N, Kieliszek AM, Tatari N, McKenna D, Singh M, Kalpana Subapanditha M, Parmar A, Mobilio D, Savage N, Lam F, Tokar T, Provias J, Lu Y, Chafe SC, Swanton C, Hynds RE, Venugopal C, Singh SK.

PubMed ID: 36780531

Sheila Singh Lab