Canada in Science - January 2023

Map of Canada featuring labs in Montreal, Toronto, Edmonton, and Saskatoon.

Past history of obesity triggers persistent epigenetic changes in innate immunity and exacerbates neuroinflammation

Journal Issue: Science. 2023 Jan 6;379(6627):45-62.

Authors: Hata M, Andriessen EMMA, Hata M, Diaz-Marin R, Fournier F, Crespo-Garcia S, Blot G, Juneau R, Pilon F, Dejda A, Guber V, Heckel E, Daneault C, Calderon V, Des Rosiers C, Melichar HJ, Langmann T, Joyal JS, Wilson AM, Sapieha P.

PubMed ID: 36603072

Przemyslaw Sapieha Lab

A universal deep-learning model for zinc finger design enables transcription factor reprogramming

Journal Issue: Nat Biotechnol. 2023 Jan 26. doi: 10.1038/s41587-022-01624-4.

Authors: Ichikawa DM, Abdin O, Alerasool N, Kogenaru M, Mueller AL, Wen H, Giganti DO, Goldberg GW, Adams S, Spencer JM, Razavi R, Nim S, Zheng H, Gionco C, Clark FT, Strokach A, Hughes TR, Lionnet T, Taipale M, Kim PM, Noyes MB.

PubMed ID: 36702896

Philip Kim Lab

Genomic atlas of the plasma metabolome prioritizes metabolites implicated in human diseases

Journal Issue: Nat Genet. 2023 Jan;55(1):44-53.

Authors: Chen Y, Lu T, Pettersson-Kymmer U, Stewart ID, Butler-Laporte G, Nakanishi T, Cerani A, Liang KYH, Yoshiji S, Willett JDS, Su CY, Raina P, Greenwood CMT, Farjoun Y, Forgetta V, Langenberg C, Zhou S, Ohlsson C, Richards JB.

PubMed ID: 36635386

Brent Richards Lab

Beta-endoproteolysis of the cellular prion protein by dipeptidyl peptidase-4 and fibroblast activation protein

Journal Issue: Proc Natl Acad Sci U S A. 2023 Jan 3;120(1):e2209815120.

Authors: Castle AR, Kang SG, Eskandari-Sedighi G, Wohlgemuth S, Nguyen MA, Drucker DJ, Mulvihill EE, Westaway D.

PubMed ID: 36574660

David Westaway Lab

Coupled induction of prophage and virulence factors during tick transmission of the Lyme disease spirochete

Journal Issue: Nat Commun. 2023 Jan 13;14(1):198. doi: 10.1038/s41467-023-35897-3.

Authors: Wachter J, Cheff B, Hillman C, Carracoi V, Dorward DW, Martens C, Barbian K, Nardone G, Renee Olano L, Kinnersley M, Secor PR, Rosa PA.

PubMed ID: 36639656

Jenny Wachter Lab