Canada in Science - July 2023

GDF15 promotes weight loss by enhancing energy expenditure in muscle

Journal Issue: Nature. 2023 Jul;619(7968):143-150. doi: 10.1038/s41586-023-06249-4.

Authors: Wang D, Townsend LK, DesOrmeaux GJ, Frangos SM, Batchuluun B, Dumont L, Kuhre RE, Ahmadi E, Hu S, Rebalka IA, Gautam J, Jabile MJT, Pileggi CA, Rehal S, Desjardins EM, Tsakiridis EE, Lally JSV, Juracic ES, Tupling AR, Gerstein HC, Paré G, Tsakiridis T, Harper ME, Hawke TJ, Speakman JR, Blondin DP, Holloway GP, Jørgensen SB, Steinberg GR.

PubMed ID: 37380764

Gregory Steinberg Lab

Fecal microbiota transplantation plus anti-PD-1 immunotherapy in advanced melanoma: a phase I trial

Journal Issue: Nat Med. 2023 Jul 6. doi: 10.1038/s41591-023-02453-x.

Authors: Routy B, Lenehan JG, Miller WH Jr, Jamal R, Messaoudene M, Daisley BA, Hes C, Al KF, Martinez-Gili L, Punčochář M, Ernst S, Logan D, Belanger K, Esfahani K, Richard C, Ninkov M, Piccinno G, Armanini F, Pinto F, Krishnamoorthy M, Figueredo R, Thebault P, Takis P, Magrill J, Ramsay L, Derosa L, Marchesi JR, Parvathy SN, Elkrief A, Watson IR, Lapointe R, Segata N, Haeryfar SMM, Mullish BH, Silverman MS, Burton JP, Maleki Vareki S.

PubMed ID: 37414899

Saman Maleki Lab

Transcriptomic classes of BCR-ABL1 lymphoblastic leukemia

Journal Issue: Nat Genet. 2023 Jul;55(7):1186-1197.

Authors: Kim JC, Chan-Seng-Yue M, Ge S, Zeng AGX, Ng K, Gan OI, Garcia-Prat L, Flores-Figueroa E, Woo T, Zhang AXW, Arruda A, Chithambaram S, Dobson SM, Khoo A, Khan S, Ibrahimova N, George A, Tierens A, Hitzler J, Kislinger T, Dick JE, McPherson JD, Minden MD, Notta F.

PubMed ID: 37337105

Faiyaz Notta Lab

LTK and ALK promote neuronal polarity and cortical migration by inhibiting IGF1R activity

Journal Issue: EMBO Rep. 2023 Jul 5;24(7):e56937.

Authors: Christova T, Ho SK, Liu Y, Gill M, Attisano L.

PubMed ID: 37186851

Liliana Attisano Lab

Excitatory neuron-specific suppression of the integrated stress response contributes to autism-related phenotypes in fragile X syndrome

Journal Issue: Neuron. 2023 Jul 13:S0896-6273(23)00476-2.

Authors: Hooshmandi M, Sharma V, Thörn Perez C, Sood R, Krimbacher K, Wong C, Lister KC, Ureña Guzmán A, Bartley TD, Rocha C, Maussion G, Nadler E, Roque PM, Gantois I, Popic J, Lévesque M, Kaufman RJ, Avoli M, Sanz E, Nader K, Hagerman RJ, Durcan TM, Costa-Mattioli M, Prager-Khoutorsky M, Lacaille JC, Martinez-Cerdeno V, Gibson JR, Huber KM, Sonenberg N, Gkogkas CG, Khoutorsky A.

PubMed ID: 37473758

Arkady Khoutorsky Lab