Canada in Science - June 2022

Mitochondrial protein import stress regulates the LC3 lipidation step of mitophagy through NLRX1 and RRBP1

Journal Issue: Mol Cell. 2022 Jun 16;S1097-2765(22)00540-8..

Authors: S, Killackey SA, Bi Y, Soares F, Hammi I, Winsor NJ, Abdul-Sater AA, Philpott DJ, Arnoult D, Girardin SE.

PubMed ID: 35752171

Small intestinal resident eosinophils maintain gut homeostasis following microbial colonization

Journal Issue: Immunity. 2022 Jun 7:S1074-7613(22)00234-5.

Authors: Ignacio A, Shah K, Bernier-Latmani J, Köller Y, Coakley G, Moyat M, Hamelin R, Armand F, Wong NC, Ramay H, Thomson CA, Burkhard R, Wang H, Dufour A, Geuking MB, McDonald B, Petrova TV, Harris NL, McCoy KD.

PubMed ID: 35709757

The metabolic enzyme hexokinase 2 localizes to the nucleus in AML and normal haematopoietic stem and progenitor cells to maintain stemness

Journal Issue: Nat Cell Biol. 2022 Jun;24(6):872-884. doi: 10.1038/s41556-022-00925-9.

Authors: Thomas GE, Egan G, García-Prat L, Botham A, Voisin V, Patel PS, Hoff FW, Chin J, Nachmias B, Kaufmann KB, Khan DH, Hurren R, Wang X, Gronda M, MacLean N, O’Brien C, Singh RP, Jones CL, Harding SM, Raught B, Arruda A, Minden MD, Bader GD, Hakem R, Kornblau S, Dick JE, Schimmer AD.

PubMed ID: 35668135

Metabolic reprogramming of skeletal muscle by resident macrophages points to CSF1R inhibitors as muscular dystrophy therapeutics

Journal Issue: Sci Transl Med. 2022 Jun 29;14(651):eabg7504. doi: 10.1126/scitranslmed.abg7504

Authors: Babaeijandaghi F, Cheng R, Kajabadi N, Soliman H, Chang CK, Smandych J, Tung LW, Long R, Ghassemi A, Rossi FMV.

PubMed ID: 35767650

Mitochondrial cyclophilin D promotes disease tolerance by licensing NK cell development and IL-22 production against influenza virus

Journal Issue: Cell Rep. 2022 Jun 21;39(12):110974. doi: 10.1016/j.celrep.2022.

Authors: Downey J, Randolph HE, Pernet E, Tran KA, Khader SA, King IL, Barreiro LB, Divangahi M.

PubMed ID: 35732121