Canada in Science - June 2024

Myelin-reactive B cells exacerbate CD4+ T cell-driven CNS autoimmunity in an IL-23-dependent manner

Journal Issue: Nat Commun. 2024 Jun 26;15(1):5404.

Authors: Mohamed Reda Fazazi, Prenitha Mercy Ignatius Arokia Doss, Resel Pereira, Neva Fudge, Aryan Regmi, Charles Joly-Beauparlant, Irshad Akbar, Asmita Pradeep Yeola, Benoit Mailhot, Joanie Baillargeon, Philippe Grenier, Nicolas Bertrand, Steve Lacroix, Arnaud Droit, Craig S. Moore, Olga L. Rojas, Manu Rangachari

PubMed ID: 38926356

Manu Rangachari Lab

Integrated single cell analysis reveals co-evolution of malignant B cells and tumor micro-environment in transformed follicular lymphoma

Journal Issue: Cancer Cell. 2024 Jun 10;42(6):1003-1017.e6.

Authors: Clémentine Sarkozy, Shaocheng Wu, Katsuyoshi Takata, Tomohiro Aoki, Susana B Neriah, Katy Milne, Talia Goodyear, Celia Strong, Tashi Rastogi, Laura K Hilton, Daniel Lai, Laurie H Sehn, Pedro Farinha, Brad H Nelson, Andrew Weng, Marco Marra, David W Scott, Jeffrey W Craig, Christian Steidl, Andrew Roth

PubMed ID: 38861923

Andrew Roth Lab

High-resolution electron cryomicroscopy of V-ATPase in native synaptic vesicles

Journal Issue: Science. 2024 Jun 20:eadp5577.

Authors: Claire E Coupland, Ryan Karimi, Stephanie A Bueler, Yingke Liang, Gautier M Courbon, Justin M Di Trani, Cassandra J Wong, Rayan Saghian, Ji-Young Youn, Lu-Yang Wang, John L Rubinstein

PubMed ID: 38900912

John L. Rubinstein Lab

Conserved role of hnRNPL in alternative splicing of epigenetic modifiers enables B cell activation

Journal Issue: EMBO Rep. 2024 Jun;25(6):2662-2697.

Authors: Poorani Ganesh Subramani, Jennifer Fraszczak, Anne Helness, Jennifer L Estall, Tarik Möröy, Javier M Di Noia

PubMed ID: 38744970

Javier Di Noia Lab

Neuromodulatory subcortical nucleus integrity is associated with white matter microstructure, tauopathy and APOE status

Journal Issue: Nat Commun. 2024 Jun 3;15(1):4706

Authors: Alfie Wearn, Stéfanie A Tremblay, Christine L Tardif, Ilana R Leppert, Claudine J Gauthier, Giulia Baracchini, Colleen Hughes, Patrick Hewan, Jennifer Tremblay-Mercier, Pedro Rosa-Neto, Judes Poirier, Sylvia Villeneuve, Taylor W Schmitz, Gary R Turner, R Nathan Spreng

PubMed ID: 38830849

R. Nathan Spreng Lab