Canada in Science - March and April 2022

Aggresome assembly at the centrosome is driven by CP110-CEP97-CEP290 and centriolar satellites

Journal Issue: Nature Commun. 2022 Apr 22;13(1):2200.

Authors: He Z, Ghorayeb R, Tan S, Chen K, Lorentzian AC, Bottyan J, Aalam SMM, Pujana MA, Lange PF, Kannan N, Eaves CJ, Maxwell CA

PubMed ID: 35459234

Allogeneic double-negative CAR-T cells inhibit tumor growth without off-tumor toxicities

Journal Issue: Sci Immunol. 2022 Apr 22;7(70):eabl3642.

Authors: Vasic D, Lee JB, Leung Y, Khatri I, Na Y, Abate-Daga D, Zhang L.

PubMed ID: 35452255

Pathogenic BRCA1 variants disrupt PLK1-regulation of mitotic spindle orientation

Journal Issue: Sci Immunol. 2022 Apr 22;7(70):eabl3642.

Authors: He Z, Ghorayeb R, Tan S, Chen K, Lorentzian AC, Bottyan J, Aalam SMM, Pujana MA, Lange PF, Kannan N, Eaves CJ, Maxwell CA

PubMed ID: 35452255

ASCL1 activates neuronal stem cell-like lineage programming through remodeling of the chromatin landscape in prostate cancer

Journal Issue: Nat Commun. 2022 Apr 27;13(1):2282..

Authors: Nouruzi S, Ganguli D, Tabrizian N, Kobelev M, Sivak O, Namekawa T, Thaper D, Baca SC, Freedman ML, Aguda A, Davies A, Zoubeidi A.

PubMed ID: 35477723

Virally programmed extracellular vesicles sensitize cancer cells to oncolytic virus and small molecule therapy

Journal Issue: Nat Commun. 2022 Apr 7;13(1):1898.

Authors: Wedge ME, Jennings VA, Crupi MJF, Poutou J, Jamieson T, Pelin A, Pugliese G, de Souza CT, Petryk J, Laight BJ, Boileau M, Taha Z, Alluqmani N, McKay HE, Pikor L, Khan ST, Azad T, Rezaei R, Austin B, He X, Mansfield D, Rose E, Brown EEF, Crawford N, Alkayyal A, Surendran A, Singaravelu R, Roy DG, Migneco G, McSweeney B, Cottee ML, Jacobus EJ, Keller BA, Yamaguchi TN, Boutros PC, Geoffrion M, Rayner KJ, Chatterjee A, Auer RC, Diallo JS, Gibbings D, tenOever BR, Melcher A, Bell JC, Ilkow CS.

PubMed ID: 35393414