Canada in Science - March and April 2024

Map of Canada featuring labs in Toronto, Montreal, Vancouver, Ottawa, and Calgary.

Proteome-scale discovery of protein degradation and stabilization effecto rs

Journal Issue: Nature. 2024 Mar 20. doi: 10.1038/s41586-024-07224-3.

Authors: Poirson J, Cho H, Dhillon A, Haider S, Imrit AZ, Lam MHY, Alerasool N, Lacoste J, Mizan L, Wong C, Gingras AC, Schramek D, Taipale M.

PubMed ID: 38509365

Mikko Taipale Lab

Proteome-scale movements and com partment connectivity during the eukaryotic cell cycle

Journal Issue: Cell. 2024 Mar 14;187(6):1490-1507.e21. doi: 10.1016/j.cell.2024.02.014.

Authors: Litsios A, Grys BT, Kraus OZ, Friesen H, Ross C, Masinas MPD, Forster DT, Couvillion MT, Timmermann S, Billmann M, Myers C, Johnsson N, Churchman LS, Boone C, Andrews BJ.

PubMed ID: 38452761

Brenda Andrews Lab

Epigenetic variation impacts individual differences in the transcriptional response to influenza infectio n

Journal Issue: Nat Genet. 2024 Mar;56(3):408-419.

Authors: Aracena KA, Lin YL, Luo K, Pacis A, Gona S, Mu Z, Yotova V, Sindeaux R, Pramatarova A, Simon MM, Chen X, Groza C, Lougheed D, Gregoire R, Brownlee D, Boye C, Pique-Regi R, Li Y, He X, Bujold D, Pastinen T, Bourque G, Barreiro LB.

PubMed ID: 38424460

Guillaume Bourque Lab

A magnetic separation method for isolating and characterizing the biomolecular corona of lipid nanopa rticles

Journal Issue: Proc Natl Acad Sci U S A. 2024 Mar 12;121(11):e2307803120.

Authors: Francia V, Zhang Y, Cheng MHY, Schiffelers RM, Witzigmann D, Cullis PR.

PubMed ID: 38437542

Pieter Cullis Lab

PHF6-mediated transcriptional control of NSC via Ephrin receptors is impaired in the intellectual disability syndrome BF LS

Journal Issue: EMBO Rep. 2024 Mar;25(3):1256-1281.

Authors: Rasool D, Burban A, Sharanek A, Madrigal A, Hu J, Yan K, Qu D, Voss AK, Slack RS, Thomas T, Bonni A, Picketts DJ, Soleimani VD, Najafabadi HS, Jahani-Asl A.

PubMed ID: 38429579

Arezu Jahani-Asl Lab

Biofilm exopolysaccharides alter sensory-neuron-mediated sickness during lung infection

Journal Issue: Cell. 2024 Apr 11;187(8):1874-1888.e14. doi: 10.1016/j.cell.2024.03.001.

Authors: Granton E, Brown L, Defaye M, Moazen P, Almblad H, Randall TE, Rich JD, Geppert A, Abdullah NS, Hassanabad MF, Hiroki CH, Farias R, Nguyen AP, Schubert C, Lou Y, Andonegui G, Iftinca M, Raju D, Vargas MA, Howell PL, Füzesi T, Bains J, Kurrasch D, Harrison JJ, Altier C, Yipp BG.

PubMed ID: 38518773

Bryan Yipp Lab

Local origin of excitatory-inhibitory tuning equivalence in a cortical netwo rk

Journal Issue: Nat Neurosci. 2024 Apr;27(4):782-792.

Authors: Duszkiewicz AJ, Orhan P, Skromne Carrasco S, Brown EH, Owczarek E, Vite GR, Wood ER, Peyrache A.

PubMed ID: 38491324

Adrien Peyrache Lab

Comprehensive whole-genome sequence analyses provide insights into the genomic architecture of cerebral pa lsy

Journal Issue: Nat Genet. 2024 Apr;56(4):585-594.

Authors: Fehlings DL, Zarrei M, Engchuan W, Sondheimer N, Thiruvahindrapuram B, MacDonald JR, Higginbotham EJ, Thapa R, Behlim T, Aimola S, Switzer L, Ng P, Wei J, Danthi PS, Pellecchia G, Lamoureux S, Ho K, Pereira SL, de Rijke J, Sung WWL, Mowjoodi A, Howe JL, Nalpathamkalam T, Manshaei R, Ghaffari S, Whitney J, Patel RV, Hamdan O, Shaath R, Trost B, Knights S, Samdup D, McCormick A, Hunt C, Kirton A, Kawamura A, Mesterman R, Gorter JW, Dlamini N, Merico D, Hilali M, Hirschfeld K, Grover K, Bautista NX, Han K, Marshall CR, Yuen RKC, Subbarao P, Azad MB, Turvey SE, Mandhane P, Moraes TJ, Simons E, Maxwell G, Shevell M, Costain G, Michaud JL, Hamdan FF, Gauthier J, Uguen K, Stavropoulos DJ, Wintle RF, Oskoui M, Scherer SW.

PubMed ID: 38553553

Stephen Scherer Lab