Canada in Science - May 2022

Map of Canada featuring lab in Montreal, Toronto, Calgary and Ottawa.

Microglia-mediated degradation of perineuronal nets promotes pain

Journal Issue: Science. 2022 May 26;eabl6773. doi: 10.1126/science.abl6773..

Authors: Tansley S, Gu N, Guzmán AU, Cai W, Wong C, Lister K, Muñoz-Pino E, Yousefpour N, Roome RB, Heal J, Wu N, Castonguay A, Lean G, Muir EM, Kania A, Prager-Khoutorsky M, Zhang J, Gkogkas CG, Fawcett JW, Diatchenko L, Ribeiro-da-Silva A, De Koninck Y, Mogil JS, Khoutorsky A.

A cellular hierarchy framework for understanding heterogeneity and predicting drug response in acute myeloid leukemia

Journal Issue: Nat Med. 2022 May 26. doi: 10.1038/s41591-022-01819-x.

Authors: Zeng AGX, Bansal S, Jin L, Mitchell A, Chen WC, Abbas HA, Chan-Seng-Yue M, Voisin V, van Galen P, Tierens A, Cheok M, Preudhomme C, Dombret H, Daver N, Futreal PA, Minden MD, Kennedy JA, Wang JCY, Dick JE.

PubMed ID: 35618837

Colony stimulating factor-1 producing endothelial cells and mesenchymal stromal cells maintain monocytes within a perivascular bone marrow niche

Journal Issue: Immunity. 2022 May 10;55(5):862-878.e8. doi: 10.1016/j.immuni.2022.04.005. Epub 2022 May 3.

Authors: Emoto T, Lu J, Sivasubramaniyam T, Maan H, Khan AB, Abow AA, Schroer SA, Hyduk SJ, Althagafi MG, McKee TD, Fu F, Shabro S, Ulndreaj A, Chiu F, Paneda E, Pacheco S, Wang T, Li A, Jiang JX, Libby P, Husain M, Wang B, Rubin BB, Cybulsky MI, Robbins CS.

PubMed ID: 35508166

Supplementation with a probiotic mixture accelerates gut microbiome maturation and reduces intestinal inflammation in extremely preterm infants

Journal Issue: Cell Host Microbe. 2022 May 11;30(5):696-711.e5..

Authors: Samara J, Moossavi S, Alshaikh B, Ortega VA, Pettersen VK, Ferdous T, Hoops SL, Soraisham A, Vayalumkal J, Dersch-Mills D, Gerber JS, Mukhopadhyay S, Puopolo K, Tompkins TA, Knights D, Walter J, Amin H, Arrieta MC.

PubMed ID: 35550672

miR-223 Exerts Translational Control of Proatherogenic Genes in Macrophages

Journal Issue: Circ Res. 2022 May 25;101161CIRCRESAHA121319120.

Authors: Nguyen MA, Hoang HD, Rasheed A, Duchez AC, Wyatt H, Lynn Cottee M, Graber TE, Susser L, Robichaud S, Berber İ, Geoffrion M, Ouimet M, Kazan H, Maegdefessel L, Mulvihill EE, Alain T, Rayner KJ.

PubMed ID: 35611698

Studies selected by Analyst Mena Abdel-Nour.