Canada in Science - May 2024

Deficiency of CBL and CBLB ubiquitin ligases leads to hyper T follicular helper cell responses and lupus by reducing BCL6 degradation

Journal Issue: Immunity. 2024 May 12:S1074-7613(24)00228-0.

Authors: Li X, Sun W, Huang M, Gong L, Zhang X, Zhong L, Calderon V, Bian Z, He Y, Suh WK, Li Y, Song T, Zou Y, Lian ZX, Gu H.

PubMed ID: 38761804

Hua Gu Lab

Assessing phage-host population dynamics by reintroducing virulent viruses to synthetic microbiomes

Journal Issue: Cell Host Microbe. 2024 May 8;32(5):768-778.e9.

Authors: Wilde J, Boyes R, Robinson AV, Daisley BA, Botschner AJ, Brettingham DJL, Macpherson CV, Mallory E, Allen-Vercoe E.

PubMed ID: 38653241

Emma Allen-Vercoe Lab

Journal Issue: Mol Cell. 2024 May 2;84(9):1802-1810.e4

Authors: Neville N, Lehotsky K, Klupt KA, Downey M, Jia Z.

PubMed ID: 38701741

Zongchao Jia Lab

Hypothalamic vasopressin sex differentiation is observed by embryonic day 15 in mice and is disrupted by the xenoestrogen bisphenol A

Journal Issue: Proc Natl Acad Sci U S A. 2024 May 21;121(21):e2313207121.

Authors: Zheng J, Baimoukhametova D, Lebel C, Bains JS, Kurrasch DM.

PubMed ID: 38753512

Deborah Kurrasch Lab

Whole genome and transcriptome integrated analyses guide clinical care of pediatric poor prognosis cancers

Journal Issue: Nat Commun. 2024 May 16;15(1):4165.

Authors: Deyell RJ, Shen Y, Titmuss E, Dixon K, Williamson LM, Pleasance E, Nelson JMT, Abbasi S, Krzywinski M, Armstrong L, Bonakdar M, Ch’ng C, Chuah E, Dunham C, Fok A, Jones M, Lee AF, Ma Y, Moore RA, Mungall AJ, Mungall KL, Rogers PC, Schrader KA, Virani A, Wee K, Young SS, Zhao Y, Jones SJM, Laskin J, Marra MA, Rassekh SR.

PubMed ID: 38755180

Shahrad Rod Rassekh Lab