Canada in Science - November 2022

Nociceptor neurons affect cancer immunosurveillance

Journal Issue: Nature. 2022 Nov;611(7935):405-412. doi: 10.1038/s41586-022-05374-w..

Authors: Balood M, Ahmadi M, Eichwald T, Ahmadi A, Majdoubi A, Roversi K, Roversi K, Lucido CT, Restaino AC, Huang S, Ji L, Huang KC, Semerena E, Thomas SC, Trevino AE, Merrison H, Parrin A, Doyle B, Vermeer DW, Spanos WC, Williamson CS, Seehus CR, Foster SL, Dai H, Shu CJ, Rangachari M, Thibodeau J, V Del Rincon S, Drapkin R, Rafei M, Ghasemlou N, Vermeer PD, Woolf CJ, Talbot S.

PubMed ID: 36323780

Mapping neurotransmitter systems to the structural and functional organization of the human neocortex

Journal Issue: Nat Neurosci. 2022 Nov;25(11):1569-1581.

Authors: Hansen JY, Shafiei G, Markello RD, Smart K, Cox SML, Nørgaard M, Beliveau V, Wu Y, Gallezot JD, Aumont É, Servaes S, Scala SG, DuBois JM, Wainstein G, Bezgin G, Funck T, Schmitz TW, Spreng RN, Galovic M, Koepp MJ, Duncan JS, Coles JP, Fryer TD, Aigbirhio FI, McGinnity CJ, Hammers A, Soucy JP, Baillet S, Guimond S, Hietala J, Bedard MA, Leyton M, Kobayashi E, Rosa-Neto P, Ganz M, Knudsen GM, Palomero-Gallagher N, Shine JM, Carson RE, Tuominen L, Dagher A, Misic B.

PubMed ID: 36303070

TRIM35-mediated degradation of nuclear PKM2 destabilizes GATA4/6 and induces P53 in cardiomyocytes to promote heart failure

Journal Issue: Sci Transl Med. 2022 Nov 2;14(669):eabm3565.

Authors: Lorenzana-Carrillo MA, Gopal K, Byrne NJ, Tejay S, Saleme B, Das SK, Zhang Y, Haromy A, Eaton F, Mendiola Pla M, Bowles DE, Dyck JRB, Ussher JR, Michelakis ED, Sutendra G.

PubMed ID: 36322626

The phosphorylation of AMPKβ1 is critical for increasing autophagy and maintaining mitochondrial homeostasis in response to fatty acids

Journal Issue: Proc Natl Acad Sci U S A. 2022 Nov 29;119(48):e2119824119

Authors: Desjardins EM, Smith BK, Day EA, Ducommun S, Sanders MJ, Nederveen JP, Ford RJ, Pinkosky SL, Townsend LK, Gutgesell RM, Lu R, Sakamoto K, Steinberg GR.

PubMed ID: 36409897

Alveolar macrophage metabolic programming via a C-type lectin receptor protects against lipo-toxicity and cell death

Journal Issue: Nat Commun. 2022 Nov 25;13(1):7272.

Authors: Scur M, Mahmoud AB, Dey S, Abdalbarri F, Stylianides I, Medina-Luna D, Gamage GS, Woblistin A, Wilson ANM, Zein HS, Stueck A, Wight A, Aguilar OA, Di Cara F, Parsons BD, Rahim MMA, Carlyle JR, Makrigiannis AP.

PubMed ID: 36433992