Canada in Science – November 2024

Stress disrupts engram ensembles in lateral amygdala to generalize threat memory in mice

Journal Issue: Nat Neurosci. 2024 Oct 8. doi: 10.1038/s41593-024-01775-4.

Authors: Lesuis SL, Park S, Hoorn A, Rashid AJ, Mocle AJ, Salter EW, Vislavski S, Gray MT, Torelli AM, DeCristofaro A, Driever WPF, van der Stelt M, Zweifel LS, Collingridge GL, Lefebvre JL, Walters BJ, Frankland PW, Hill MN, Josselyn SA.

PubMed ID: 39549697

Sheena Josselyn Lab

PIEZO-dependent mechanosensing is essential for intestinal stem cell fate decision and maintenance

Journal Issue: Science. 2024 Nov 29;386(6725):eadj7615. doi: 10.1126/science.adj7615

Authors: Baghdadi MB, Houtekamer RM, Perrin L, Rao-Bhatia A, Whelen M, Decker L, Bergert M, Pérez-Gonzàlez C, Bouras R, Gropplero G, Loe AKH, Afkhami-Poostchi A, Chen X, Huang X, Descroix S, Wrana JL, Diz-Muñoz A, Gloerich M, Ayyaz A, Matic Vignjevic D, Kim TH.

PubMed ID: 39607940

Tae-Hee Kim Lab

PARP enzyme de novo synthesis of protein-free poly(ADP-ribose)

Journal Issue: Mol Cell. 2024 Nov 7:S1097-2765(24)00864-5. doi: 10.1016/j.molcel.2024.10.024

Authors: Langelier MF, Mirhasan M, Gilbert K, Sverzhinksy A, Furtos A, Pascal JM.

PubMed ID: 39536748

John Pascal Lab

Identification of a non-canonical planar cell polarity pathway triggered by light in the developing mouse retina

Journal Issue: Housset M, Filion D, Cortes N, Vali H, Mandato CA, Casanova C, Cayouette M.

Authors: Housset M, Filion D, Cortes N, Vali H, Mandato CA, Casanova C, Cayouette M.

PubMed ID: 39561777

Michel Cayouette Lab

GSK3 inhibition improves skeletal muscle function and whole-body metabolism in male mouse models of Duchenne muscular dystrophy

Journal Issue: Nat Commun. 2024 Nov 25;15(1):10210.

Authors: Marcella BM, Hockey BL, Braun JL, Whitley KC, Geromella MS, Baranowski RW, Watson CJF, Silvera S, Hamstra SI, Wasilewicz LJ, Crozier RWE, Marais AAT, Kim KH, Lee G, Vandenboom R, Roy BD, MacNeil AJ, MacPherson REK, Fajardo VA.

PubMed ID: 39587049

Val Fajardo Lab