Canada in Science - October 2022

Single-cell genomic variation induced by mutational processes in cancer

Journal Issue: Nature. 2022 Oct 26. doi: 10.1038/s41586-022-05249-0.

Authors: Funnell T, O’Flanagan CH, Williams MJ, McPherson A, McKinney S, Kabeer F, Lee H, Salehi S, Vázquez-García I, Shi H, Leventhal E, Masud T, Eirew P, Yap D, Zhang AW, Lim JLP, Wang B, Brimhall J, Biele J, Ting J, Au V, Van Vliet M, Liu YF, Beatty S, Lai D, Pham J, Grewal D, Abrams D, Havasov E, Leung S, Bojilova V, Moore RA, Rusk N, Uhlitz F, Ceglia N, Weiner AC, Zaikova E, Douglas JM, Zamarin D, Weigelt B, Kim SH, Da Cruz Paula A, Reis-Filho JS, Martin SD, Li Y, Xu H, de Algara TR, Lee SR, Llanos VC, Huntsman DG, McAlpine JN; IMAXT Consortium, Shah SP, Aparicio S

PubMed ID: 36289342

Genome-wide rare variant score associates with morphological subtypes of autism spectrum disorder

Journal Issue: Nat Commun. 2022 Oct 29;13(1):6463. doi: 10.1038/s41467-022-34112-z.

Authors: Chan AJS, Engchuan W, Reuter MS, Wang Z, Thiruvahindrapuram B, Trost B, Nalpathamkalam T, Negrijn C, Lamoureux S, Pellecchia G, Patel RV, Sung WWL, MacDonald JR, Howe JL, Vorstman J, Sondheimer N, Takahashi N, Miles JH, Anagnostou E, Tammimies K, Zarrei M, Merico D, Stavropoulos DJ, Yuen RKC, Fernandez BA, Scherer SW.

PubMed ID: 36309498

CDK12 is hyperactivated and a synthetic-lethal target in BRAF-mutated melanoma

Journal Issue: Nat Commun. 2022 Oct 29;13(1):6457. doi: 10.1038/s41467-022-34179-8.

Authors: Houles T, Lavoie G, Nourreddine S, Cheung W, Vaillancourt-Jean É, Guérin CM, Bouttier M, Grondin B, Lin S, Saba-El-Leil MK, Angers S, Meloche S, Roux PP.

PubMed ID: 36309522

Nuclear mRNA metabolism drives selective basket assembly on a subset of nuclear pore complexes in budding yeast

Journal Issue: Mol Cell. 2022 Oct 20;82(20):3856-3871.e6. doi: 10.1016/j.molcel.2022.09.019.

Authors: Bensidoun P, Reiter T, Montpetit B, Zenklusen D, Oeffinger M.

PubMed ID: 36220102

Marker-free co-selection for successive rounds of prime editing in human cells

Journal Issue: Nat Commun. 2022 Oct 7;13(1):5909. doi: 10.1038/s41467-022-33669-z.

Authors: Levesque S, Mayorga D, Fiset JP, Goupil C, Duringer A, Loiselle A, Bouchard E, Agudelo D, Doyon Y.

PubMed ID: 36207338