Canada in Science - October 2023

Antagonistic roles of canonical and Alternative-RPA in disease-associated tandem CAG repeat instability

Journal Issue: Cell. 2023 Oct 26;186(22):4898-4919.e25.

Authors: Gall-Duncan T, Luo J, Jurkovic CM, Fischer LA, Fujita K, Deshmukh AL, Harding RJ, Tran S, Mehkary M, Li V, Leib DE, Chen R, Tanaka H, Mason AG, Lévesque D, Khan M, Razzaghi M, Prasolava T, Lanni S, Sato N, Caron MC, Panigrahi GB, Wang P, Lau R, Castel AL, Masson JY, Tippett L, Turner C, Spies M, La Spada AR, Campos EI, Curtis MA, Boisvert FM, Faull RLM, Davidson BL, Nakamori M, Okazawa H, Wold MS, Pearson CE.

PubMed ID: 37827155

Christopher Pearson Lab

The mesencephalic locomotor region recruits V2a reticulospinal neurons to drive forward locomotion in larval zebrafish

Journal Issue: Nat Neurosci. 2023 Oct;26(10):1775-1790.

Authors: Carbo-Tano M, Lapoix M, Jia X, Thouvenin O, Pascucci M, Auclair F, Quan FB, Albadri S, Aguda V, Farouj Y, Hillman EMC, Portugues R, Del Bene F, Thiele TR, Dubuc R, Wyart C

PubMed ID: 37667039

Miguel Ramalho-Santos Lab

ctDNA response after pembrolizumab in non-small cell lung cancer: phase 2 adaptive trial results

Journal Issue: Nat Med. 2023 Oct;29(10):2559-2569.

Authors: Anagnostou V, Ho C, Nicholas G, Juergens RA, Sacher A, Fung AS, Wheatley-Price P, Laurie SA, Levy B, Brahmer JR, Balan A, Niknafs N, Avrutin E, Zhu L, Sausen M, Bradbury PA, O’Donnell-Tormey J, Gaudreau PO, Ding K, Dancey J.

PubMed ID: 37814061

Janet Dancey Lab

Immune responses to gut bacteria associated with time to diagnosis and clinical response to T cell-directed therapy for type 1 diabetes prevention

Journal Issue: Sci Transl Med. 2023 Oct 25;15(719):eadh0353.

Authors: Xie QY, Oh S, Wong A, Yau C, Herold KC, Danska JS.

PubMed ID: 37878676

Jayne Danska Lab

Phage display uncovers a sequence motif that drives polypeptide binding to a conserved regulatory exosite of O-GlcNAc transferase

Journal Issue: Proc Natl Acad Sci U S A. 2023 Oct 17;120(42):e2303690120

Authors: Alteen MG, Meek RW, Kolappan S, Busmann JA, Cao J, O’Gara Z, Chou Y, Derda R, Davies GJ, Vocadlo DJ.

PubMed ID: 37819980

David Vocadlo Lab