Canada in Science – October 2024

Modeling Parkinson’s disease pathology in human dopaminergic neurons by sequential exposure to α-synuclein fibrils and proinflammatory cytokines

Journal Issue: Nat Neurosci. 2024 Oct 8. doi: 10.1038/s41593-024-01775-4.

Authors: Bayati A, Ayoubi R, Aguila A, Zorca CE, Deyab G, Han C, Recinto SJ, Nguyen-Renou E, Rocha C, Maussion G, Luo W, Shlaifer I, Banks E, McDowell I, Del Cid Pellitero E, Ding XE, Sharif B, Séguéla P, Yaqubi M, Chen CX, You Z, Abdian N, McBride HM, Fon EA, Stratton JA, Durcan TM, Nahirney PC, McPherson PS.

PubMed ID: 39379564

Peter McPherson Lab

Prediction of brain metastasis development with DNA methylation signatures

Journal Issue: Nat Med. 2024 Oct 8. doi: 10.1038/s41591-024-03286-y.

Authors: Zuccato JA, Mamatjan Y, Nassiri F, Ajisebutu A, Liu JC, Muazzam A, Singh O, Zhang W, Voisin M, Mirhadi S, Suppiah S, Wybenga-Groot L, Tajik A, Simpson C, Saarela O, Tsao MS, Kislinger T, Aldape KD, Moran MF, Patil V, Zadeh G.

PubMed ID: 39379704

Gelareh Zadeh Lab

Embryonic macrophages support endocrine commitment during human pancreatic differentiation

Journal Issue: Cell Stem Cell. 2024 Oct 10:S1934-5909(24)00325-4.

Authors: Migliorini A, Ge S, Atkins MH, Oakie A, Sambathkumar R, Kent G, Huang H, Sing A, Chua C, Gehring AJ, Keller GM, Notta F, Nostro MC.

PubMed ID: 39406230

Maria Cristina Nostro Lab

AlphaFold-Multimer accurately captures interactions and dynamics of intrinsically disordered protein regions

Journal Issue: Proc Natl Acad Sci U S A. 2024 Oct 29;121(44):e2406407121.

Authors: Omidi A, Møller MH, Malhis N, Bui JM, Gsponer J.

PubMed ID: 39446390

Jörg Gsponer Lab

Transcriptional coactivator MED15 is required for beta cell maturation

Journal Issue: Nat Neurosci. 2024 Oct 8. doi: 10.1038/s41593-024-01775-4.

Authors: Kadhim AZ, Vanderkruk B, Mar S, Dan M, Zosel K, Xu EE, Spencer RJ, Sasaki S, Cheng X, Sproul SLJ, Speckmann T, Nian C, Cullen R, Shi R, Luciani DS, Hoffman BG, Taubert S, Lynn FC.

PubMed ID: 39379383

Francis Lynn Lab