Canada in Science - September 2022

Regulation of alternative polyadenylation by the C2H2-zinc-finger protein Sp1

Journal Issue: Mol Cell. 2022 Sep 1;82(17):3135-3150.e9.

Authors: Song J, Nabeel-Shah S, Pu S, Lee H, Braunschweig U, Ni Z, Ahmed N, Marcon E, Zhong G, Ray D, Ha KCH, Guo X, Zhang Z, Hughes TR, Blencowe BJ, Greenblatt JF.

PubMed ID: 35914531

An ADP-ribosyltransferase toxin kills bacterial cells by modifying structured non-coding RNAs

Journal Issue: Mol Cell. 2022 Sep 15;82(18):3484-3498.e11.

Authors: Bullen NP, Sychantha D, Thang SS, Culviner PH, Rudzite M, Ahmad S, Shah VS, Filloux A, Prehna G, Whitney JC.

PubMed ID: 36070765

GABA facilitates spike propagation through branch points of sensory axons in the spinal cord

Journal Issue: Nat Neurosci. 2022 Sep 26. doi: 10.1038/s41593-022-01162-x.

Authors: Hari K, Lucas-Osma AM, Metz K, Lin S, Pardell N, Roszko DA, Black S, Minarik A, Singla R, Stephens MJ, Pearce RA, Fouad K, Jones KE, Gorassini MA, Fenrich KK, Li Y, Bennett DJ.

PubMed ID: 36163283

ER-resident STIM1/2 couples Ca2+ entry by NMDA receptors to pannexin-1 activation

Journal Issue: Proc Natl Acad Sci U S A. 2022 Sep 6;119(36):e2112870119.

Authors: Patil CS, Li H, Lavine NE, Shi R, Bodalia A, Siddiqui TJ, Jackson MF.

PubMed ID: 36037373

3D chromatin remodeling potentiates transcriptional programs driving cell invasion

Journal Issue: Proc Natl Acad Sci U S A. 2022 Sep 6;119(36):e2203452119.

Authors: Lebeau B, Jangal M, Zhao T, Wong CK, Wong N, Cañedo EC, Hébert S, Aguilar-Mahecha A, Chabot C, Buchanan M, Catterall R, McCaffrey L, Deblois G, Kleinman C, Park M, Basik M, Witcher M.

PubMed ID: 36037342